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Table 1 Classes of pet mutants

From: Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae

Class

Respiration after mating with Δmip1

Respiration after cytoduction

Associated gene functions

I

-

-

Genes essential for maintenance of mtDNA (16 mutants); or genes essential for respiration with gradual loss of mtDNA (102 mutants)

II

+

+

Additional effects of extra-genomic factors and/or acquired mitochondrial damage (23 mutants)

III

+

-

Genes essential for respiration but not for maintenance of mtDNA (134 mutants)

IV

-

+

Genes dispensable for respiration, gradual loss of mtDNA (44 mutants)