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Figure 1 | Genome Biology

Figure 1

From: Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection

Figure 1

Venn diagram of numbers of haploinsufficient and haploproficient genes after removal of bad tags and dubious ORFs. Haploinsufficient genes are often shared between all three drug conditions; genes involved in heat shock response show a similar phenotype. IBA and ALE appear to have an overlapping mode of action on genes associated with secondary N-BP targets, such as chromatin structure, but not on primary, mevalonate-dependent interactions, while RIS and IBA share the main N-BP target, the farnesyl transferase ERG20, part of the mevalonate pathway.

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Genome Biology

ISSN: 1474-760X

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