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Table 1 List of candidates

From: A global survey identifies novel upstream components of the Ath5 neurogenic network

Name Fold-change ID
Group 1: repressors in RPCs   
   AATF 0.21 ± 0.02 Rb-binding protein Che-1
   ARG1 0.27 ± 0.02 Liver-type arginase
   ATP-synthase 0.28 ± 0.04 ATP synthase beta chain
   Cnot10 0.15 ± 0.01 CCR4-NOT transcription complex, subunit 10
   DuS4L 0.28 ± 0.01 tRNA-dihydrouridine synthase 4-like
   KPNA4 0.25 ± 0.04 Importin alpha-4 subunit
   MCM2 0.27 ± 0.00 DNA replication licensing factor 2
   USP25 0.28 ± 0.05 Ubiquitin carboxyl-terminal hydrolase 25
   WDR43 0.29 ± 0.04 WD repeat protein 43, unknown function
Group 2: activators in RPCs   
   Bcat2 2.93 ± 0.27 Mitochondrial branched chain aminotransferase 2
   Cbx7 2.96 ± 0.14 Polycomb group gene
   CEB55 4.70 ± 0.39 Centrosomal protein of 55 kDa
   GPI deacetylase 15.00 ± 0.81 Vesicular transport
   PTPN2 3.65 ± 0.59 Tyrosine-protein phosphatase non-receptor
   Rb1 3.50 ± 0.46 Cell cycle exit, transcription factor
   SRP40 2.88 ± 0.10 Splicing factor
   Sterol demethylase 3.33 ± 0.33 Sterols and steroids biosynthesis, oocyte maturation
   Thiolase 4.98 ± 0.32 Trifunctional enzyme, acetyl-CoA transferase
   TMEM79 3.01 ± 0.30 Transmembrane protein, function unclear
   TMP49 3.92 ± 0.42 Transmembrane protein, function unknown
   Transferase 3.39 ± 0.58 Arginine n-methyl-transferase
   Bub3 4.85 ± 0.00 Mitotic checkpoint protein
   FAN 3.28 ± 0.28 Associated with N-SMase activation
   Hsp1 11.02 ± 1.36 Heat shock protein 1
   KPNA2 3.65 ± 0.36 Importin alpha-2 subunit,
   MCM3 3.00 ± 0.00 DNA replication licensing factor 3
   MRPL47 3.33 ± 0.00 Mitochondrial ribosomal protein L47 isoform b
   NHL-domain II 3.36 ± 0.59 NHL-domain containing, unknown function
   Ribonuclease 4.15 ± 0.09 Ribonuclease HI large subunit
   sFRP-1 2.97 ± 0.55 Wnt-signal regulator
   TARBP2 3.05 ± 0.18 TAR RNA-binding protein 2
   Tetraspanin-9 3.29 ± 0.00 Transmembrane protein, interacts with integrins
   USP1 3.25 ± 0.34 Ubiquitin carboxyl-terminal hydrolase 1
Group 3: activators in RGCs   
   Ndrg3a 3.73 ± 0.00 N-myc downstream regulated 3, function unknown
   Islet2 5.11 ± 0.22 Insulin gene enhancer, transcription factor
   Tetraspanin-31 3.00 ± 0.38 Transmembrane protein, unknown function
Group 4: repressors in RGCs   
   ELG protein 0.27 ± 0.00 mRNP complex, unknown function
   Idax 0.16 ± 0.01 Negative regulation of Wnt signaling
   NHL-protein 0.27 ± 0.00 NHL-domain containing, unknown function
   RBM4L 0.23 ± 0.01 RRM-class RNA-binding protein
   RBPMS2 0.20 ± 0.06 RNA-binding protein RNP-1, unknown function
   Zfp 161 0.23 ± 0.01 Zinc finger, function unclear
Ubiquitously expressed regulators   
   HMG 2.93 ± 0.49 HMG box DNA-binding domain
   p65 TF 6.16 ± 0.81 NF-κB transcription factor p65
   Beta-actin 0.27 ± 0.03 Cytoskeleton
   Tubulin alpha-1B chain 3.28 ± 0.59 Cytoskeleton
   UBR2 3.18 ± .0.36 Ubiquitin-protein ligase E3 component N-recognin-2
   Uncharacterized1 0.22 ± 0.01 Unknown function
   Coiled-coil domain 3.25 ± 0.43 Unknown function
   EF-1-alpha 3.31 ± 0.26 Elongation factor
   Nfkbia 2.99 ± 0.44 NF-kappaB inhibitor
   Ankrd39 5.40 ± 0.71 Ankyrin repeat domain-containing protein 39, unknown function
  1. Candidate clones were selected based on their relative effect on the reporter construct. Out of this list, clones with a specific spatio-termporal expression in the eye were grouped into four categories (groups 1 to 4). An additional category contains clones expressed ubiquitously. For each clone the fold-change of reporter activity with standard deviation and a short description of the gene are shown.