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Figure 5 | Genome Biology

Figure 5

From: Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

Figure 5

FLN-based disease gene prioritization shows improvement over PPI network. Gene-centric assessment (as described in the legend of Figure 4b) is used to compare the disease-gene prioritization performances between the integrated FLN and a representative PPI network. The PPI network is composed of curated PPI databases [45–51], along with high-throughput PPI data from yeast two-hybrid and mass spectrometry [52–54], and interactions mapped from PPI of other model organisms. The artificial chromosomal region composed of a collection of 100 nearest genes flanking each tested disease gene physically on the chromosome is used as the background gene set. Here, we exclude text mining data from the FLN.

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Genome Biology

ISSN: 1474-760X

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