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Table 2 Correlation between the results obtained using the ARR and RE-score calculation methods

From: mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer

  PITA PicTar
Dataset Percentage (ER- > ER+) Percentage (ER- < ER+) Spearman correlation Percentage (ER- > ER+) Percentage (ER- < ER+) Spearman correlation
HE 58% 23% 0.861 77% 12% 0.752
MI 100% 0% 0.646 60% 16% 0.778
MN 73% 10% 0.668 62% 17% 0.763
VA 86% 2% 0.659 65% 5% 0.578
WA 68% 18% 0.855 59% 22% 0.837
  1. Percentage (ER- > ER+): the fraction of microRNAs with ARR < 1 and t-score < 0, indicating that the microRNAs show higher regulatory activity in ER- than in ER+ samples, as consistently supported by both the ARR method and RE-score expression comparison method. Percentage (ER- < ER+): the fraction of microRNAs with RR > 1 and t-score > 0. These microRNAs show higher regulatory activity in ER+ samples, as supported by both the ARR method and the RE-score expression comparison method. Spearman correlation: the correlation between the ARR value and t-score (ER-/ER+).