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Figure 2 | Genome Biology

Figure 2

From: MouseCyc: a curated biochemical pathways database for the laboratory mouse

Figure 2

Oxidative ethanol degradation pathway in the mouse. (a) Initial PathoLogic prediction assigned six enzymes to EC 1.1.1.1, five enzymes for EC 1.2.1.3 and one enzyme for EC 6.2.1.13 reactions. (b) Manually resolved pathway for Mus musculus. The association of Adh6b with EC 1.1.1.1 was removed because, while no functional studies of ADH6B enzyme have been reported yet, the protein lacks Phe140, a strictly conserved residue in ethanol-active enzymes [32]. For EC 1.2.1.3, the list of genes was updated with only those aldehyde dehydrogenase superfamily members that have experimental evidence of involvement in ethanol metabolism. Finally, the last reaction in this pathway is EC 6.2.1.1, rather than EC 6.2.1.13, which is implicated in lipid biosynthesis. This posted correction to the MetaCyc database was propagated to the MouseCyc pathway using the PathoLogic incremental update tool. (c) The MouseCyc server permits direct comparison of a mouse biochemical pathway with the same pathway from an external PGDB, HumanCyc [19].

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