Oxidative ethanol degradation pathway in the mouse. (a) Initial PathoLogic prediction assigned six enzymes to EC 184.108.40.206, five enzymes for EC 220.127.116.11 and one enzyme for EC 18.104.22.168 reactions. (b) Manually resolved pathway for Mus musculus. The association of Adh6b with EC 22.214.171.124 was removed because, while no functional studies of ADH6B enzyme have been reported yet, the protein lacks Phe140, a strictly conserved residue in ethanol-active enzymes . For EC 126.96.36.199, the list of genes was updated with only those aldehyde dehydrogenase superfamily members that have experimental evidence of involvement in ethanol metabolism. Finally, the last reaction in this pathway is EC 188.8.131.52, rather than EC 184.108.40.206, which is implicated in lipid biosynthesis. This posted correction to the MetaCyc database was propagated to the MouseCyc pathway using the PathoLogic incremental update tool. (c) The MouseCyc server permits direct comparison of a mouse biochemical pathway with the same pathway from an external PGDB, HumanCyc .