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Table 2 Human claudin genes and transcript information

From: The claudins

Gene Localization Introns Transcript information Protein size Molecular weight Pi
CLDN1 3q28 3 One form 211 22,744 8.41
CLDN2 Xq22 1 One form 230 24,549 8.47
CLDN3 7q11 0 One form 220 23,319 8.37
CLDN4 7q11 0 One form 209 22,077 8.38
CLDN5 22q11 1 Two variants: alternative splicing, coding unaffected 218 23,147 8.25
CLDN6 16p13 1 One form 220 23,292 8.32
CLDN7 17p13 3 One form 211 22,390 8.91
CLDN8 21q22 0 One form 225 24,845 9
CLDN9 16p13 1 One form 217 22,848 6.54
CLDN10 13q31 1 Two variants: alternative transcription start site, different amino termini a: 226 24,251 9.24
     b: 228 24,488 8.32
CLDN11 3q26 2 One form 207 21,993 8.22
CLDN12 7q21 2 One form 244 27,110 8.8
CLDN14 21q22 2 Two variants: alternative splicing, coding unaffected 239 25,699 8.94
CLDN15 7q11 4 One form 228 24,356 5.61
CLDN16 3q28 4 One form 305 33,836 8.26
CLDN17 21q22 0 One form 224 24,603 9.8
CLDN18 3q34 4 Two variants: alternative transcription start site, different amino termini a: 261 27,856 8.39
     b: 261 27,720 8.39
CLDN19 1p34 4 Two variants: alternative splicing, different carboxyl termini a: 224 23,229 8.48
     b: 211 22,076 7.52
CLDN20 6q25 1 One form 219 23,515 6.98
CLDN21 11q23 0 One form 229 25,393 5.37
CLDN22 4q35 0 One form 220 25,509 5.37
CLDN23 8p23 0 One form 292 31,915 7.51
CLDN24 4q35 0 One form 205 22,802 4.87
  1. The chromosomal localization, intron number, and transcript details are indicated for each of the claudin genes, together with the size (in amino acids), molecular weight (in Da), and isoelectric point (Pi) of their encoded proteins. CLDN10, CLDN18, and CLDN19 have two variants giving rise to slightly different proteins. Only the variants documented in GenBank are indicated and other variants may exist.