Known CRMs tend to be among the regions more highly bound in vivo. The 1% FDR bound regions for (a) HKB 1, (b) MED 2, (c) TLL 1 and (d) TWI were each divided into cohorts based on peak window score (x-axis). The fraction of all bound regions in each cohort (red bars) are shown (y-axis). In (a, c), the fraction of bound regions in each cohort in which the peak 500-bp window overlaps a CRM known to be regulated by at least some A-P early factors is shown (green bars). In (b, d), the fraction of bound regions that overlap a CRM known to be regulated by at least some D-V factors are shown (blue bars). The number of bound regions in each cohort is given above the bars.