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Table 4 High scoring and corresponding low scoring multi-species conserved elements

From: Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons

Cluster Gene MCE Score Control Score
1 CAMK2N1 CAMK2N1.3 548.29 No control MCE*  
   CAMK2N1.4 152.32   
1 SCAMP5 SCAMP5.1 476.64 SCAMP5.7 0
   SCAMP5.30 90.5   
1 SNAP25 SNAP25.78 479.98 SNAP25.76 0
1 STXBP1 STXBP1.7 479.61 STXBP1.1 0
1 RAB3C RAB3C.32 96.13 RAB3C.28-9 0
1 SYN1 SYN1.11 1006.13 No control MCE*  
   SYN1.10 234.92   
1 RAB3A RAB3A.MCE1 997.88 No control MCE*  
   RAB3A.MCE2 98.63   
2 CAMK2G CAMK2G.23 520.43 CAMK2G.22 0
2 NAPG NAPG.18 522.09 NAPG.7 0
3 CAMK1G CAMK1G.523 639.59 CAMK1G.528 0
3 RIMS1 RIMS1.394 680.61 RIMS1.389 0
3 STX18 STX18.12* 627.98 STX18.15 0
3 SYT8 SYT8.4 508.56 SYT8.2 0
  1. The list of 16 high scoring multi-species conserved elements (MCEs) and 10 low scoring MCEs for experimental validation (see Materials and method for selection detail). *Genomic regions upstream of CAMK2N1, SYN1 and Rab3A genes do not contain low-scoring MCEs. One of the high-scoring MCEs (STX18.12) failed to be cloned. A Luciferase assay in the Neuro2a cell line identified neuronal enhancers in 12 high-scoring MCEs and 3 low-scoring MCEs marked in bold (Student's t-test, P < 0.05).