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Table 4 High scoring and corresponding low scoring multi-species conserved elements

From: Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons

Cluster

Gene

MCE

Score

Control

Score

1

CAMK2N1

CAMK2N1.3

548.29

No control MCE*

 
  

CAMK2N1.4

152.32

  

1

SCAMP5

SCAMP5.1

476.64

SCAMP5.7

0

  

SCAMP5.30

90.5

  

1

SNAP25

SNAP25.78

479.98

SNAP25.76

0

1

STXBP1

STXBP1.7

479.61

STXBP1.1

0

1

RAB3C

RAB3C.32

96.13

RAB3C.28-9

0

1

SYN1

SYN1.11

1006.13

No control MCE*

 
  

SYN1.10

234.92

  

1

RAB3A

RAB3A.MCE1

997.88

No control MCE*

 
  

RAB3A.MCE2

98.63

  

2

CAMK2G

CAMK2G.23

520.43

CAMK2G.22

0

2

NAPG

NAPG.18

522.09

NAPG.7

0

3

CAMK1G

CAMK1G.523

639.59

CAMK1G.528

0

3

RIMS1

RIMS1.394

680.61

RIMS1.389

0

3

STX18

STX18.12*

627.98

STX18.15

0

3

SYT8

SYT8.4

508.56

SYT8.2

0

  1. The list of 16 high scoring multi-species conserved elements (MCEs) and 10 low scoring MCEs for experimental validation (see Materials and method for selection detail). *Genomic regions upstream of CAMK2N1, SYN1 and Rab3A genes do not contain low-scoring MCEs. One of the high-scoring MCEs (STX18.12) failed to be cloned. A Luciferase assay in the Neuro2a cell line identified neuronal enhancers in 12 high-scoring MCEs and 3 low-scoring MCEs marked in bold (Student's t-test, P < 0.05).