Single tissue projections to the adipose-hypothalamus TTC network. (a) Adipose and hypothalamus modules (color shaded rectangles) derived from independent analysis of each tissue's GGC network and their overlap with the AH network. Each tissue-specific module is shaded based on the percentage overlap relative to the module size (the shading scale shown next to the modules). The black lines between modules represent edges identified in the AH network. (b) Percentage overlap of GGC modules relative to the TTC network: top adipose modules and bottom hypothalamus modules. The black stairs show the percentage overlap that is observed by chance. The yellow bar represents genes that were not placed in single tissue modules and contains approximately 40% of all genes found in the TTC network. (c) Percentage overlaps between the subset of adipose and hypothalamus genes from the AH network and the adipose genes (top panel) and hypothalamus genes (bottom panel). Each bar represents the percentage of genes with connectivity k in the corresponding single tissue (the x-axis) that are part of the TTC network. We can see that expression traits that do not correlate with many other traits in a single tissue are more likely to be found in the TTC network.