Skip to main content
Figure 2 | Genome Biology

Figure 2

From: Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data

Figure 2

Correlation of features with percentage of disorder in the proteome. (a) Variation in absolute transcript expression as the percentage of disorder increases in the proteome (yellow bars). The bar charts represent the average sample expression for the groups of transcripts separated according to the percentage range (x-axis) of the total disordered residues in the encoded proteins. The y-axis scale represents log2 absolute expression. Expression levels for the transcripts with MF and BP GO terms at level 4 are shown as light green and dark green bars, respectively. (b) Variation of mRNA decay rate as disorder increases in the proteome. mRNA decay rates versus the percentage bins of disordered residues are shown. (c) Variation of protein stability as disorder increases in the proteome. The stability index versus the percentage bins of disordered residues are shown. (d) The proportion of protein coding transcripts targeted by miRNA (y-axis) as the percentage of disorder increases in the proteome. The datasets for the transcripts encoding the disordered proteins (burgundy) and ordered proteins (mauve) and the proteome (yellow) are shown. (e) The percentage of the proteins with one or more predicted ubiquitination sites against the percentage of disorder (principal y-axis, bar charts); and the percentage of residues predicted as ubiquitination sites against the percentage of disorder (secondary y-axis, line plots). The transcripts encoding the disordered proteins, the ordered proteins and the proteome are shown in burgundy, mauve and yellow (respectively).

Back to article page