Figure 8

Three-dimensional models of the human HoxA cluster during cellular differentiation. 5C array datasets from (a) undifferentiated and (b) differentiated samples were used to predict models of the HoxA cluster with the 5C3D program. Green lines represent genomic DNA and vertices define boundaries between consecutive restriction fragments. Colored spheres represent transcription start sites of HoxA genes as described in the legend. (c) Increased local genomic density surrounding 5' HoxA transcription start sites accompanies cellular differentiation. The y-axis indicates local genomic density and HoxA paralogue groups are identified on the x-axis. A linear schematic representation of the HoxA cluster is shown at the top, and green shading highlights the region of greatest density change. Error bars represent standard deviations.