Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii

Table 3 Gene Ontology categories significantly enriched among motif-containing genes

Motif	GO category	Description	p-value	Adjusted p-value
GLYCB	GO:0016530	Metallochaperone activity	1.00E-05	0.0004
MICB	GO:0016530	Metallochaperone activity	1.00E-05	0.0004
NTBA	GO:0022414	Reproductive process	1.00E-06	0.0001
NTBA	GO:0016530	Metallochaperone activity	1.00E-05	0.0004
NTBB	GO:0002376	Immune system process	1.00E-06	0.0002
NTBB	GO:0009987	Cellular process	0.0005	0.0110
NTBB	GO:0009055	Electron carrier activity	0.0025	0.0371
NTBB	GO:0008152	Metabolic process	0.0026	0.0367
NTBB	GO:0030234	Enzyme regulator activity	0.0030	0.0400
RPA	GO:0045735	Nutrient reservoir activity	1.00E-06	0.0001
RPA	GO:0005840	Ribosome	1.45E-06	0.0001
RPA	GO:0005198	Structural molecule activity	3.65E-06	0.0002
RPA	GO:0006412	Translation	0.0001	0.0039
RPA	GO:0009987	Cellular process	0.0004	0.0096
RPA	GO-0043226	Organelle	0.0005	0.0110
RPA	GO-0032991	Macromolecular complex	0.0005	0.0107
RPA	GO:0051234	Establishment localization	0.0008	0.0148
RPA	GO:0051179	Localization	0.0008	0.0156
RPB	GO-0044421	Extracellular region part	1.00E-07	3.52E-05
RPB	GO:0022414	Reproductive process	1.00E-06	0.0001
RPB	GO:0016530	Metallochaperone activity	1.00E-05	0.0003
RPB	GO:0006412	Translation	0.0001	0.0020
RPB	GO:0005840	Ribosome	0.0003	0.0074
RPB	GO-0043226	Organelle	0.0010	0.0172
RPB	GO:0009987	Cellular process	0.0018	0.0285
RPB	GO:0005198	Structural molecule activity	0.0018	0.0282

Significantly enriched GO categories (adjusted p-value < 0.05) for motif-containing genes. The results are listed by each motif and ordered based on their Benjamini Hochberg adjusted p-value. A good correlation is observed between the functional pathways associated with the seed genes and the GO category that is over-represented in the corresponding motif-containing genome-wide gene sets in the case of motifs NTBB, RPA and RPB.

ISSN: 1474-760X