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Table 1 Relevant pathways for methanogenesis

From: Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes

Dataset

ReliefF

SVMAttributeEval

Wrapper (naïve Bayes)

Complete (266)

Reduction of CO2 to CH4 (methane1) ↑

Reduction of CO2 to CH4 (methane1) ↑

Reduction of CO2 to CH4 (methane1) ↑

 

Biosynthesis of cardiolipin (phospholipids1) ↓

Biosynthesis of cardiolipin (phospholipids1) ↓

Degradation of L-lysine to crotonyl-CoA (lysine3) ↓

 

Biosynthesis of peptidoglycan I (aminosugars4) ↓

beta-Oxidation of fatty acids (fa2) ↓

Biosynthesis of coenzyme A (coa1) ↓

 

Heme biosynthesis (pyrrole3) ↓

Degradation of L-threonine to L-2-aminoacetate (threonine2) ↓

 
 

Pentose phosphate cycle (non-oxidative branch) (ppc3) ↓

Biosynthesis of phosphatidylserine (phospholipids3) ↑

 

Archaea (23)

Biosynthesis of 2'-deoxythymidine-5'-triphosphate (dtn1) ↑

Biosynthesis of 2'-deoxythymidine-5'-triphosphate (dtn1) ↑

Reduction of CO2 to CH4 (methane1) ↓

 

Reduction of CO2 to CH4 (methane1) ↑

Biosynthesis of L-phenylalanine from chorismate (aaa4) ↑

Biosynthesis of 2'-deoxythymidine-5'-triphosphate (dtn1) ↑

 

Biosynthesis of phosphatidylserine (phospholipids3) ↑

Reduction of CO2 to CH4 (methane1) ↑

Degradation of L-threonine to L-2-aminoacetate (threonine2) ↓

 

Degradation of L-threonine to L-2-aminoacetate (threonine2) ↓

Degradation of dGMP to deoxyguanosine (dgn2) ↓

Degradation of L-lysine to crotonyl-CoA (lysine3) ↓

 

Degradation of tryptophane to 6-hydroxymelatonin (trp5) ↑

Biosynthesis of phosphatidylserine (phospholipids3) ↑

Biosynthesis of coenzyme B12 (coba1) ↑

Archaea (23) (without methane1)

Biosynthesis of 2'-deoxythymidine-5'-triphosphate (dtn1) ↑

Biosynthesis of 2'-deoxythymidine-5'-triphosphate (dtn1) ↑

Biosynthesis of 2'-deoxythymidine-5'-triphosphate (dtn1) ↑

 

Biosynthesis of phosphatidylserine (phospholipids3) ↑

Biosynthesis of L-phenylalanine from chorismate (aaa4) ↑

Biosynthesis of coenzyme B12 (coba1) ↑

 

Degradation of L-threonine to L-2-aminoacetate (threonine2) ↓

Degradation of L-threonine to L-2-aminoacetate (threonine2) ↓

Degradation of L-valine (vas4) ↓

 

Degradation of tryptophane to 6-hydroxymelatonin (trp5) ↑

Biosynthesis of phosphatidylserine (phospholipids3) ↑

Degradation of L-threonine to L-2-aminoacetate (threonine2) ↓

 

Biosynthesis of coenzyme B12 (coba1) ↑

Odd-numbered fatty acid metabolism (glf2) ↓

Degradation of L-lysine to crotonyl-CoA (lysine3) ↓

  1. The relevant pathways for methanogenesis were determined by applying three different attribute selection methods (ReliefF, SVMAttributeEval, and a wrapper for the naïve Bayes classifier) to three datasets. The (up to) five most relevant pathways received for the complete set of pathway profiles (266 genomes), the archaeal pathway profiles (23 genomes), and the archaea profiles (23 genomes) without the attribute 'methane1' are shown. An upwards pointing arrow denotes pathways that are relevant due to higher pathway scores (that is, pathways are more complete) in methanogens compared to the other genomes in the investigated dataset. In analogy, a downwards pointing arrow denotes pathways that are relevant due to lower pathway scores (that is, pathways are less complete) in methanogens.