Figure 2

Homology between Orc6 in representative species D. melanogaster (Dm), H. sapiens (Hs), A. thaliana (At), S. pombe (Sp), and S. cerevisiae (Sc). Orc6 contains a unique conserved domain, identified by homology with the Orc6 protein fold superfamily (pfam 05460) [76]. This domain is interrupted by a large disordered region [77] in S. cerevisiae. Orc6 has no recognizable homology to Orc1-5 or AAA+ domains. The carboxy-terminal region of Orc6 in D. melanogaster has been shown to interact with a coiled-coil region of the septin protein Pnut, possibly mediated by coiled-coil motifs predicted in Orc6 [78]. The number of amino acids for each protein is indicated at the right.