Figure 1

Amplification event surrounding pfmdr1 on chromosome 5 in Dd2. The log₂ ratio of the intensity of each unique probe in Dd2 was divided by the intensity of each unique probe in 3D7 to generate the plot. The probe log ratios were colored by the moving average over a 500 base pair window as indicated in the color bar. A normal distribution around zero was expected if the copy number was the same. The ends of chromosome 5 are highly polymorphic subtelomeric regions and thus showed much lower probe intensity in Dd2 when compared with the reference 3D7. The amplification containing 14 genes including pfmdr1 (marked with an asterisk) is enlarged in the inset. Mb, megabases.