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Table 1 Viral titer (PFU/ml) for A/Puerto Rico/8/1934 (PR8/34) and A/New Caledonia/20/1999 (NC/99) H1N1 strains, and for A/Wisconsin/67/2005 (Wisc/05) H3N2 strain

From: The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus

  PR8/34 A/H1N1 NC/99 A/H1N1 Wisc/05 A/H3N2
  48 h 96 h 48 h 96 h 48 h 72 h
37°C 2.5 × 108 4.2 × 109 1.0 × 105 1.1 × 109 1.0 × 105 >106
39°C 1.7 × 108 7.4 × 109 <100 <104 3.0 × 103 3.2 × 106
40°C 1.0 × 108 2.0 × 108 <100 <104 <100 <100
  1. The folding energies for segments 1-3, and 5 are: PR8/34, [-671.33, -633.85, -604.73, -473.22]; NC/99, [-658.78, -615.39, -611.74, -477.67]; Wisc/05, [-637.74, -617.08, -593.41, -455.20].