Genetic interactions within protein complexes. (a, b) Percent of gene pairs within complexes that have a negative GI between them. (a) Complexes with at least 20% negative interactions. (b) Complexes with at least 20% positive interactions. (c, d) Examples of representative protein complexes enriched with negative (c) or positive (d) GIs. For each complex the matrix presents the combined measured and predicted data. Measured GIs are marked by a yellow dot. No GIs were measured in the complexes in (c). Essential gene names are in red.