Figure 4

Effect of variable ITRs on the coding sequence of nuclear pore interacting proteins. (a) Amino acid sequences encoded by the ITR units of the human morpheus paralog BAG65049 were taken as representatives. Type 1 repeats are associated with two different units of 57 bp and 69 bp, respectively, and are translated into two different frames. This results in four distinct amino acid repeats (1a, 1b, 1c and 1d). Type 2 repeats are much simpler and only produce one sequence. Amino acids are highlighted according to the Clustal color scheme [71]. (b) Representation of the protein sequences encoded by the human paralogs of exon 8 of morpheus. Only proteins associated with transcripts shown in Table 3 are reported. (c) Cartoon of the possible three-dimensional structural organization of morpheus, based on secondary structure predictions (see text). These predictions were confirmed also for the other RefSeq transcripts. The representation is not to scale.