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Table 3 Independent duplications and parallel relocalizations in the human and yeast lineages have happened multiple times during evolution

From: Expansion of the human mitochondrial proteome by intra- and inter-compartmental protein duplication

  Human Yeast
Family Mitochondrial Non-mitochondrial Mitochondrial Non-mitochondrial
Thioredoxins TXN, TXN2 TXNDC2 TRX3 TRX1, TRX2
Glutaredoxins GLRX2 GLRX, GLRXL GRX2 GRX1 (nucleus)
Isocitrate dehydrogenases [NADP] IDH2 IDH1 IDP1 IDP2, IDP3 (peroxisome)
Branched-chain-amino-acid aminotransferases BCAT2 BCAT1 BAT1 BAT2
Serine hydroxymethyltransferases SHMT2 SHMT1 SHM1 SHM2
  1. Rows show proteins targeted to mitochondria and their paralogs targeted to other subcellular compartments in both human and yeast. Non-mitochondrial homologs (both human and yeast) are cytosolic if not indicated otherwise.