Table 2 Dating of gene duplication of mitochondrial proteins compared to time when the mitochondrial targeting signal appeared in the protein sequence
From: Expansion of the human mitochondrial proteome by intra- and inter-compartmental protein duplication
Paralogs | Duplication before the divergence of | Targeting signal found in |
|---|---|---|
TOP1MT, TOP1 | Vertebrates | Vertebrates (Gallus gallus) |
TFB2M, DIMT1L | Animals | Animals (Anopheles gambiae) |
NUDT8, NUDT7 | Animals | Animals (Drosophila melanogaster) |
SIRT3, SIRT2 | Coelomata to chordata* | Vertebrates (Danio rerio) |
HTRA2, HTRA1 | Vertebrates | Vertebrates (Danio rerio) |
PDE12, CNOT6 | Animals | Chordates (Ciona intestinalis) |
PECI, CDYL | Animals | Animals (Caenorhabditis elegans) |
HINT2, HINT1 | Animals | Animals (Drosophila melanogaster) |
GOT2, GOT1 | Animals | Animals (Drosophila melanogaster) |