Figure 6

Human-mouse conservation of occupancy classes and transitions among the classes. The arrows represent transitions between human and mouse at the aligned CTCF site locations. The numbers next to arrows represent the fraction of times that transition was observed in the real data; those in parentheses show the mean and standard deviation of this transition probability based on 1,000 simulations, according to a stringent evolutionary model. Green colored arrows indicate that the observed transition probability was significantly greater (simulation based P-value ≤ 0.05) than expected and red colored arrows indicate that the observed transition probability was significantly smaller than expected. The light green shaded arrows indicate near-significance (0.05 <P-value ≤ 0.07). (a) Based on the CTCF sites shared among the four cell types. (b) Based on all CTCF sites in CD4+ cells.