Figure 7

Canonical pathway and gene network analysis of the 37 classifiers. (a) The 37 classifiers were analyzed using ingenuity pathway analysis and the classifiers were grouped to 12 canonical biological process pathways. The antigen presentation pathway (7 molecules) and protein ubiquitination pathway (5 molecules) were found to be the dominant canonical pathways represented by these set of classifiers. The orange squares indicate the ratio of the number of genes from the dataset that map to the canonical pathway, whilst the solid blue bars correspond to the P-value representing the probability that the association between the genes in the classifier set and the identified pathway occurs by chance alone (calculated by Fischer's exact test, and given as a log P-value). A representative gene network of the dominant canonical pathways was then generated (b). Transcripts that are overexpressed in patients with melioidosis are indicated by a red color. The function of the gene product is represented by a symbol. Connections between the gene products and the nature of these interactions are shown.