Table 2 Functional signatures of differentially expressed genes induced or suppressed in H- ras ^-/- and/or N- ras ^-/- fibroblasts after serum stimulation for 8 hours (G1 progression)

Up-regulated genes

   GO:0003723

RNA binding

15.9%

0,000055

H-ras^-/-

Eif2s1, Rnu3ip2, Nola2, Cpsf4, Rnpc1, Mrpl20, Ddx18, Sf3a1, Hnrpll, Lsm8

   GO:0006412

Protein biosynthesis

11.1%

0,000405

H-ras^-/-

Iars, Tars, Eif2s1, Eftud2, Nola2, Rpp30, Mrpl20

   GO:0030529

Ribonucleoprotein complex

9.5%

0,001480

H-ras^-/-

Eftud2, Rnu3ip2, Nola2, Mrpl20, Hnrpll, Lsm8

   GO:0000398

mRNA splicing

6.3%

0,002982

H-ras^-/-

Rnps1, Eftud2, Sf3a1, Lsm8

   GO:0003743

Translation initiation factor activity

4.8%

0,007354

H-ras^-/-

Eif2s1, Eif4ebp1, AU014645

   GO:0000074

Regulation of cell cycle

4.8%

0,045790

H-ras^-/-

Ccnd2, Junb, Kras

   GO:0005578

Extracellular matrix interaction

9.8%

0,000006

N-ras^-/-

Col18a1, Mmp10, Mmp13, Mmp9

   GO:0005634

Cell cycle

14.6%

0,000057

N-ras^-/-

Ccne2, Mcm5, Rbl1, Trp53, Cdc6

   GO:0006260

DNA replication

12,2%

0,000035

N-ras^-/-

Mcm5, Pold1, Rrm2, Myst2, Cdc6

   GO:0006915

Apoptosis

12.2%

0,002126

N-ras^-/-

Birc5, Bcap29, Perp, Tnfrsf11b, Trp53

Down-regulated genes

   GO:0003677

Transcription

21.4%

0,003721

N-ras^-/-

Ankrd1, Meis1, Tcf20