Divergence of exonic splicing elements after gene duplication and the impact on gene structures

Table 3 ESE and ESS net changes in human duplicates

		All	P	Non- synonymous	P	Synonymous	P
ESEs	Mean	-0.3123	1.54E-05	-0.0642	0.1403	-0.2122*	2.93E-06
	High	0.0228	0.4164	0.0308	0.2124	-0.0240	0.4879
	Low	-0.3147	7.6E-13	-0.0809	0.0023	-0.1870*	1.25E-08
ESSs	Mean	0.0272	0.3491	-0.0087	0.9629	0.0163	0.5235
	High	0.1106	1.37E-07	0.0285	0.0301	0.0604*	0.0001
	Low	-0.0992	1.72E-05	-0.0354	0.0095	-0.0559	0.0007

*The contribution of synonymous mutations to the net change of elements is significantly larger than that of nonsynonymous mutations (P < 0.05). In each cell, the number is the mean net change for each exon that is caused by mutations. Positive values mean more creation than disruption, and negative values the reverse. The 'mean' group merges the changes in each paralogous exon pair, while the High and Low groups include one of two paralogous exons with the higher or lower ESE/ESS density, respectively. The number of homologous clusters used in this analysis is 921.

ISSN: 1474-760X