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Figure 4 | Genome Biology

Figure 4

From: The SR protein family

Figure 4

Localization of SR proteins within the nucleus. Left panel: HeLa cells transfected with GFP-SRp20. The GFP fluorescence is visualized directly. Middle panel: cells are also stained with anti-SC35 hybridoma supernatant to highlight clusters of SR proteins in the nucleus (red), which are referred to as nuclear speckles. Speckles are believed to be storage compartments for SR proteins and other splicing factors. Right panel: merge of GFP-SRp20 and SC35 images. The bar in each panel indicates the scale. Images courtesy of Lin Li and Rozanne Sandri-Goldin.

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