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Table 2 Functional annotation analysis of exon hubs or gene hubs

From: Studying alternative splicing regulatory networks through partial correlation analysis

  

Corrected p-value for hubs of EG networks

Corrected p-value for hubs of EE networks

Corrected p-value for hubs of GG networks

Category

Term

Human

Mouse

Rat

Human

Mouse

Rat

Human

Mouse

Rat

SP

Alternative splicing

2.4 × 10-13

6.3 × 10-25

2.6 × 10-10

1.0 × 10-21

5.3 × 10-20

3.0 × 10-19

N

N

N

UP

Splice variant

1.7 × 10-06

5.2 × 10-14

5.3 × 10-05

8.4 × 10-12

4.9 × 10-08

1.6 × 10-11

N

N

N

MF

Binding

2.3 × 10-05

8.0 × 10-05

N

1.8 × 10-07

3.1 × 10-06

3.1 × 10-04

N

N

N

SP

Phosphoprotein

1.4 × 10-17

8.9 × 10-09

N

1.7 × 10-16

2.0 × 10-07

5.3 × 10-07

N

N

N

MF

Protein binding

2.2 × 10-08

2.7 × 10-04

N

8.0 × 10-08

1.1 × 10-04

1.7 × 10-07

N

N

N

CC

Intracellular

2.6 × 10-07

1.0 × 10-15

N

1.2 × 10-20

2.7 × 10-06

N

N

N

N

CC

Intracellular part

8.6 × 10-09

6.1 × 10-13

N

9.4 × 10-20

9.0 × 10-07

N

N

N

N

SP

Cytoplasm

N

2.6 × 10-08

N

N

6.4 × 10-08

N

5.8 × 10-04

N

N

CC

Cytoplasm

5.3 × 10-04

5.5 × 10-11

N

N

2.6 × 10-07

N

N

N

N

CC

Intracellular organelle

2.2 × 10-05

N

N

9.4 × 10-18

N

N

N

6.5 × 10-04

N

CC

Organelle

2.4 × 10-05

N

N

1.0 × 10-17

N

N

N

6.7 × 10-04

N

SP

Coiled coil

N

1.6 × 10-05

N

N

8.2 × 10-06

N

N

N

N

BP

Cellular component organization and biogenesis

N

N

N

2.5 × 10-04

N

3.8 × 10-04

N

N

N

CC

Intracellular organelle part

N

N

N

4.6 × 10-05

N

N

N

1.9 × 10-04

N

BP

Macromolecule metabolic process

5.9 × 10-05

N

N

2.5 × 10-08

N

N

N

N

N

CC

Nucleus

N

N

N

1.2 × 10-14

N

N

N

1.3 × 10-06

N

SP

Nucleus

N

N

N

1.9 × 10-10

N

N

N

8.1 × 10-05

N

CC

Organelle part

N

N

N

5.9 × 10-05

N

 

N

2.0 × 10-04

N

CC

Synapse

N

N

N

N

3.0 × 10-04

1.1 × 10-15

N

N

N

BP

Transport

N

N

9.7 × 10-04

N

 

7.1 × 10-14

N

N

N

  1. The DAVID functional annotation tool was applied to genes whose exons are the hubs of EG networks, genes whose exons are the hubs of EE networks, and genes that are the hubs of GG networks. The listed gene annotation terms have at least five gene counts, have p-values after Bonferroni's correction ≤ 0.001, and appear at least twice in the nine groups (EG, EE, and GG for human, mouse, and rat). 'N' means the term is not significant for this group. The annotation terms considered here are from the default settings. SP, SP_PIR_KEYWORDS where PIR means protein information resource. UP, UP_SEQ_FEATURE, which means Uniprot sequence feature. BP, GOTERM_BP_ALL where BP means biological process. CC, GOTERM_CC_ALL where CC means cellular component. MF, GOTERM_MF_ALL where MF means molecular function.