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Table 4 Examples of genes encoding modulators of signaling pathways that show changes in splice junctions upon wingless pathway activation

From: Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophilacells

Gene name Type of AS Effect of AS Expression Function
rotound Exon skipping Alternative coding sequence No change wingless expression regulation
syndecan Alternative 3' splice site Alternative 5' UTR Upregulated Heparan sulfate proteoglycan
IP3k2 Alternative 5' splice site Alternative 5' UTR Upregulated Inositol 3P 3-ki-nase activity
sprint Alternative promoter; Alternative polyadenyl. Alternative VPS9 and Ras-association Potentially upregulated Ras GTPase binding
cdep Exon skipping Alternative Ferm_3 domain No change Regulation of Rho signaling
pink1 Alternative 3' splice site Alternative 5' UTR No change Serine/threonine kinase
CG15611 Exon skipping Alternative coding sequence Downregulated Regulation of Rho signaling
smi35A Complex exon skipping Alternative 5' UTR Upregulated Tyr-phosphorylation regulated kinase
eip63E Alternative promoter Alternative 5' UTR and coding sequence Upregulated Cyclin-dependent protein kinase
  1. Modulators of signaling activities are described, together with the type of alternative splicing event, predicted consequences for the transcript/protein and function in the pathway (as retrieved from Flybase and literature). AS, alternative splicing.
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Genome Biology

ISSN: 1474-760X

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