Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophilacells

Table 4 Examples of genes encoding modulators of signaling pathways that show changes in splice junctions upon wingless pathway activation

Gene name	Type of AS	Effect of AS	Expression	Function
rotound	Exon skipping	Alternative coding sequence	No change	wingless expression regulation
syndecan	Alternative 3' splice site	Alternative 5' UTR	Upregulated	Heparan sulfate proteoglycan
IP3k2	Alternative 5' splice site	Alternative 5' UTR	Upregulated	Inositol 3P 3-ki-nase activity
sprint	Alternative promoter; Alternative polyadenyl.	Alternative VPS9 and Ras-association	Potentially upregulated	Ras GTPase binding
cdep	Exon skipping	Alternative Ferm_3 domain	No change	Regulation of Rho signaling
pink1	Alternative 3' splice site	Alternative 5' UTR	No change	Serine/threonine kinase
CG15611	Exon skipping	Alternative coding sequence	Downregulated	Regulation of Rho signaling
smi35A	Complex exon skipping	Alternative 5' UTR	Upregulated	Tyr-phosphorylation regulated kinase
eip63E	Alternative promoter	Alternative 5' UTR and coding sequence	Upregulated	Cyclin-dependent protein kinase

Modulators of signaling activities are described, together with the type of alternative splicing event, predicted consequences for the transcript/protein and function in the pathway (as retrieved from Flybase and literature). AS, alternative splicing.

ISSN: 1474-760X