Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophilacells

Table 3 Examples of genes encoding signaling pathway components that show changes in splice junctions upon wingless pathway activation

Gene name	Type of AS	Effect of AS	Expression	Function
Fz2	Alternative promoter	Alternative 5' UTR	Upregulated	Wnt receptor activity
dawdle	Alternative promoter	Alternative 5' UTR	Upregulated	TGF-β receptor binding
baboon	Mutually exclusive exons	Alternative activin receptor domain	No change	TGF-β type I receptor
stat92E	Alternative promoter; exon skipping	Alternative stat interaction domain	No change	JAK/STAT signaling
hr51	Multiple exon skipping	Alternative coding sequence	No change	Steroid hormone receptor

Pathway components are described, together with the type of alternative splicing event, predicted consequences for the transcript/protein and function in the pathway (as retrieved from Flybase and literature). AS, alternative splicing.

ISSN: 1474-760X