Table 4 Biological relationships used in guilt-by-association GO term predictions
Relationship evidence type | No. of gene pairs with evidence | Sourcea |
|---|---|---|
Affinity capture-MS | 19,115 | Gavin et al. [56] |
Two-hybrid | 9,598 | Ito et al. [4] |
Synthetic lethality | 9,067 | Tong et al. [57] |
Synthetic growth defect | 5,131 | Pan et al. [58] |
Biochemical activity | 4,822 | Ptacek et al. [59] |
Affinity capture-western | 3,584 | Kang et al. [60] |
Epistatic miniarray profile | 3,416 | Schuldiner et al. [61] |
Dosage rescue | 2,493 | Gandhi et al. [62] |
Synthetic rescue | 1,667 | Valachovic et al. [63] |
Phenotypic enhancement | 1,468 | Myung et al. [64] |
Reconstituted complex | 1,345 | Kus et al. [65] |
Co-purification | 898 | Stevens et al. [66] |
Phenotypic suppression | 589 | Mosch et al. [67] |
Dosage lethality | 373 | Branzei et al. [68] |
Co-fractionation | 319 | Xu et al. [69] |
Co-localization | 208 | Shen et al. [70] |
Co-crystal structure | 72 | Cramer et al. [71] |
Protein-peptide | 63 | Mariño-Ramirez et al. [72] |
Affinity capture-RNA | 52 | Tharun et al. [73] |
Far western | 36 | Tsai et al. [74] |
Dosage growth defect | 33 | Pan et al. [75] |
FRET | 32 | Damelin et al. [76] |
Protein-RNA | 6 | Gonsalvez et al. [77] |
Total | 55,039 |