Predictions for the ε domain of casein kinase 1 reconciled by isotonic regression. The figure is the same as Figure 3, but the predicted probabilities have been reconciled by isotonic regression. The graph shows a portion of the molecular function GO, corresponding to positive labels and labels predicted with probability larger than 0.1. Each term's outline is colored according to the label with respect to the target term 'protein-tyrosine kinase activity'. A green outline corresponds to a positive label, and a purple outline corresponds to a negative label. The interior of each node is colored following a similar color scheme (green = 1 and purple = 0), according to the predicted probability.