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Table 2 Estimation of tumor cell content from simulated data using segmentation

From: Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays

Tumor Tumor cells using hemizygous loss (%)* Tumor cells using single copy gain (%)† Tumor cells using copy neutral LOH (%)‡
cells (%) Paired Unpaired Paired Unpaired Paired Unpaired
0 - - - - - -
5 - - - - - -
10 - - - - - -
15 - - - - 15 15
20 - - - - 21 21
25 26 26 - - 25 25
30 30 30 31 31 30 30
35 35 35 36 36 35 35
40 40 40 41 41 40 40
45 45 45 45 45 45 45
50 50 50 50 50 49 49
55 55 55 55 55 55 55
60 59 59 60 60 60 61
65 65 65 65 65 64 65
70 70 70 70 70 69 70
75 75 75 75 75 75 75
80 80 80 80 80 80 80
85 85 85 85 85 85 84
90 90 90 90 90 89 86
95 95 93 96 96 94 88
100 99 95 101 101 97 89
  1. *Hemizygous loss on chromosome 10q23.1-q23.33. †Mono allelic gain on chromosome 8p. ‡Copy neutral LOH on 17p13.1-p12. Dashes indicate 'not detected'.
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Genome Biology

ISSN: 1474-760X

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