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Figure 10 | Genome Biology

Figure 10

From: Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays

Figure 10

Theoretical and observed mBAF values for different types of allelic imbalances with increasing tumor content for the CRL-2324 dilution series. (a) Linearity of segmented mBAF values for the copy neutral LOH region on 13q21.31-qter across the CRL-2324 dilution series. The red line corresponds to expected mBAF values and the gray line to a linear regression fit for experimental data between 0% and 100% tumor content, for which c represents the tumor fraction. (b) Theoretical mBAF values for different allelic imbalances: hemizygous loss (black line), copy number neutral LOH (red line), single copy gain (green line), and 4N amplification, for example, BBBA (blue line).

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