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Table 2 Top 10 pairs of multi-protein complexes that present 'between' synthetic genetic interactions

From: Modeling synthetic lethality

       Essential genes
Complex 1/complex 2 P-values (adjusted) Odds Expected Interact Tested Complex 1 Complex 2
Condensed kinetochore [GO:0000778]/prefoldin [GO:0016272] 5.54e-86 350.66 0.50 49 68 19 0
Outer kinetochore [MIPS-270.20]/prefoldin [GO:0016272] 1.51e-72 Inf 0.26 35 35 12 0
Prefoldin [GO:0016272]/SWR1 [GO:0000812] 7.05e-50 326.96 0.30 29 41 0 5
Ctf3 [GO:0016272]/prefoldin [GO:0005868] 1.61e-36 674.97 0.18 20 24 0 0
Prefoldin [MIPS-270.20.20]/cytoplasmic dynein [GO:0016272] 7.23e-30 Inf 0.11 15 15 0 0
Ctf18 RFC-like [GO:0016272]/prefoldin [GO:0005869] 5.78e-27 674. 13 0.13 15 18 0 0
Prefoldin [GO:0031390]/Dynactin [GO:0016272] 5.78e-27 674. 13 0.13 15 18 4 0
Dynein motorproteins [MIPS-140.30.30.20]/prefoldin [GO:0016272] 5.78e-27 674. 13 0.13 15 18 0 0
Dynactin [MIPS-140.30.30.30]/prefoldin [GO:0016272] 5.78e-27 674. 13 0.13 15 18 0 0
Kinetochore [GO:0000776]/condensed kinetochore [GO:0000778] 3.24e-25 85.47 0.36 19 49 7 19
  1. Top 10 pairs of multi-protein complexes that present between synthetic genetic interactions in Tong et al. [10]. P-values (adjusted), Bonferroni adjusted P-value of the hypergeometric test; Odds, odds ratios; Expected, expected number of synthetic genetic interactions between multi-protein complexes; Interact, number of synthetic genetic interactions observed (positive edges); Tested, number of interactions (edges) tested; Essential genes, number of essential genes in multi-protein complexes 1 and 2, respectively. Note that when all the tested interactions are synthetic genetic interactions (tested = interact) the odds ratios are infinite (Inf).