Figure 2
From: The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition
miR-17-5p is sufficient to drive a proliferative signal in HEK293T cells. (a) Graph displaying the significance of functional enrichment for PicTar predicted targets of miR-17-5p and miR-20a from the miR-17-92 cluster. Arrows indicate the mean significance of randomly selected gene sets of equivalent size, and the grey boxes show ± 4 standard deviations. (b) Graph displaying the significance of enrichment for genes acting at the G1/S cell cycle boundary. (c) Graph depicting the proliferation rates of HEK293T cells transiently transfected with miR-17-5p precursor dsRNA and those transfected with control dsRNA. (d) Graph depicting proliferation rates of HEK293T cells stably over-expressing plasmid-expressed miR-17-5p and HEK293T cells stably selected for the plasmid-control.