Figure 1

Illustrative examples of ChIP-enrichment ratios of (a, b, e) OCT4 and (c, d, f) NANOG bound regions obtained from ChIP-chip experiments with promoter arrays (a-d) and chromosome 19 arrays (e, f). The chromosomal position of the genes, as well as the genomic scale, is represented along the x-axis. The fold enrichment of the probes is shown on the y-axis. These enrichment ratios represent the medians of the per-pixel ratios scanned at each spot on the microarray. Exons and introns are represented by boxes and horizontal lines, respectively. The transcription start site and direction of transcription are denoted by arrows. (g) Venn diagram depicting the overlap between gene whose promoters were bound by both OCT4 and NANOG in ChIP-chip experiments (p-value < 0.001).