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Figure 3 | Genome Biology

Figure 3

From: Diarrhea as a cause of mortality in a mouse model of infectious colitis

Figure 3

Genes contributing to host susceptibility. (a) Comparative analysis of gene expression profiles of SW versus FVB genes prior to infection or at 4 and 9 dpi is shown as a Venn diagram. Overall, 1,547 genes were differentially expressed between the lines of mice (Additional data file 5) and divided into 7 distinct subsets. Group A represents genes that were differentially expressed between the mouse lines at all time points. Groups B, C, and D represent genes that were differentially expressed at two conditions/time points. Groups E, F, and G represent genes unique to uninfected status, 4 dpi and 9 dpi, respectively. Each subset represents the comparison of resistant outbred SW mice to susceptible inbred FVB mice at the indicated time point. Numbers in parentheses represent the number of differentially expressed probe sets in each group. Significantly enriched GO clusters (p < 0.05 by hypergeometric test) for each group and for all sets of genes with host effect are given in Additional data file 20. (b) PCA distinguished SW from FVB mice in PC2. PC1 established negative correlation of infected and uninoculated FVB mice, but did not discriminate SW mice by infection status. Thus, PC1 represents morbidity associated with infection. (c) The prevalence of genes within GO categories was assessed by FatiGO analysis. Only categories containing more than 5% of genes are shown. Genes from transport processes were overrepresented.

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