From: Isolated populations and complex disease gene identification
Complex disease/trait | Gene/locus | Population/isolate | Reference |
---|---|---|---|
Affective disorders | Several loci | Northern Sweden | [34] |
Asthma | IRAK-M (interleukin-1 receptor-associated kinase M) | Sardinia | [74] |
Asthma | CHI3L1 (chitinase 3-like 1) | Hutterites | [25] |
Asthma | NPSR1 (neuropeptide S receptor 1) | Finland | [24] |
Atrial fibrillation | 4q25 | Iceland | [11] |
Bipolar disorder | 5q31-34 | Antioquia (Colombia), Central Valley of Costa Rica | [29] |
Bone mineral density | Several loci | Iceland | [75] |
Breast cancer | 5p12, 2q35, 16q12 | Iceland | |
Myocardial infarction | 9p21 | Iceland | |
Coronary heart disease | 8p22 | French Canadians | [79] |
Crohn's disease | Several loci | French Canadians | [80] |
Fasting glucose levels | G6PC2 (glucose-6-phosphatase, catalytic, 2)/ABCB11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11) region | Finland, Sardinia | [81] |
Exfoliation glaucoma | LOXL1 (lysyl oxidase-like 1) | Iceland | [82] |
Height | Several loci | Iceland | [13] |
Height | GDF5 (growth differentiation factor 5)/UQCC (ubiquinol-cytochrome c reductase complex chaperone) locus | Finland, Sardinia, Amish | [83] |
Nicotine dependence and smoking-related diseases | 15q24 | Iceland | [84] |
Obesity | FTO (fat mass and obesity associated), PFKP (phosphofructokinase, platelet) | Sardinia | [28] |
Parkinson's disease | GBA (β-glucocerebrosidase) | Ashkenazi Jews | [37] |
Pigmentation | Several genes | Iceland | |
Prostate cancer | Xp11.22, 2p15, 17q | Iceland | |
Psychotic and bipolar spectrum disorders | TSNAX (translin-associated factor X)/DISC1(disrupted in schizophrenia 1) locus | Finland | [86] |
Psychosis | TGIF (TGFB-induced factor) | Central Valley of Costa Rica | [87] |
Schizophrenia | DRD2 (dopamine D2 receptor) | Basques | [30] |
Type 2 diabetes | CDKAL1 (CDK5 regulatory subunit associated protein 1-like 1) | Iceland | [10] |