Multiple sequence alignment of the Cand2 (At3g05010.1) and Cand8 (At5g27210.1) family. The family is widely conserved beyond the Oryza and Populus proteomes; homologous sequences can be found in other dicotyledonous plants (grape [GenBank:CAN61534.1]), monocotyledonous plants (sorghum [GenBank:AAM47585.1]), insects (honeybee [GenBank:XP_625021.2]), and mammals (mouse GPR175 protein [GenBank:AAH10244.1]). The long carboxy-terminal region of the honeybee and mouse protein sequences are truncated due to the lack of any meaningful alignment beyond that shown. Schematic above the alignment blocks indicates the 7TM topology of Cand2, as predicted by TMHMM. Blue lines, extracellular regions; blue blocks, TM domains; red lines, intracellular regions.