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Table 5 Gene expression levels for genes encoding critical surface markers

From: The IL-10 and IFN-γ pathways are essential to the potent immunosuppressive activity of cultured CD8+NKT-like cells

Symbol Function NKT/nCD8 CD4/nCD8 aCD8/nCD8 NKT/nCD8 (q) CD4/nCD8 (q) aCD8/nCD8 (q)
Ifitm1 Suppression 89.9 7.1 1.5 2.8E-07 2.2E-03 2.4E-01
Lilrb4 (ILT3) Suppression 50.3 43.8 7.6 3.6E-04 4.0E-05 5.6E-03
Ifitm2 Suppression 45.6 11.4 1.6 6.0E-07 2.1E-03 2.8E-01
Havcr2 (Tim3) Suppression 36.5 10.4 0.7 1.6E-04 2.0E-03 2.4E-01
Tnfrsf9 (4-1BB) Suppression 28.2 12.5 12.8 2.4E-04 3.2E-03 1.1E-02
Tnfsf6 (FASL) Suppression 24.4 4.3 3.2 1.2E-05 6.1E-02 4.5E-02
Ifitm3 Suppression 24.3 15.6 0.8 2.5E-05 1.4E-03 6.6E-01
Ctla4 Suppression 5.3 18.7 21.5 2.8E-03 4.8E-03 2.7E-03
Tnfrsf18 (GITR) Suppression 4.8 11.1 4.4 2.7E-03 4.3E-05 1.7E-02
Pdcd1lg2 Suppression 4.6 7.3 3.3 5.4E-04 2.5E-04 3.0E-02
Icos Suppression 4.6 4.0 3.6 2.8E-03 3.5E-03 3.2E-02
Tnfsf11 (RANKL) Suppression 3.9 8.1 27.0 7.6E-03 2.4E-03 3.4E-03
Tnfsf10 (TRAIL) Suppression 3.1 3.2 1.8 2.7E-03 9.5E-03 6.6E-02
Tnfrsf4 (OX40) Suppression 3.0 23.8 11.3 1.6E-02 7.6E-06 5.7E-03
P2ry14 (Gpr105) Receptor 65.4 6.9 1.1 2.1E-05 2.3E-03 6.8E-01
Fcer1g Receptor 12.7 0.7 0.7 7.4E-04 1.4E-02 2.2E-01
Ptger3 Receptor 12.0 1.2 1.1 3.5E-04 2.3E-01 6.9E-01
Il12rb1 Receptor 10.6 11.3 4.0 8.9E-04 2.7E-05 1.8E-02
Ltb4r1 Receptor 8.8 1.2 0.9 2.9E-03 1.8E-01 7.0E-01
Gabarapl1 Receptor 8.7 5.3 3.4 2.4E-04 1.8E-03 1.4E-01
Ly6a Receptor 7.3 11.3 3.0 3.5E-04 1.7E-04 5.3E-02
Tcrg Receptor 6.3 0.2 0.3 1.9E-03 1.4E-03 6.9E-02
Il12rb2 Receptor 5.8 18.2 6.2 1.1E-04 1.6E-04 1.0E-02
Pilrb Receptor 5.8 0.9 0.8 1.1E-03 1.5E-01 5.2E-01
Tmem2 Receptor 5.8 4.6 2.0 5.4E-03 8.5E-04 1.1E-01
Gpr171 Receptor 4.6 7.4 2.9 8.8E-03 1.3E-03 1.2E-01
Gpr34 Receptor 4.5 0.6 0.7 2.7E-02 1.1E-02 3.6E-01
Gpr160 Receptor 3.7 1.1 1.4 4.8E-03 3.0E-01 3.5E-01
Oprm1 Receptor 0.20 0.08 0.49 1.6E-03 3.6E-04 1.1E-01
Tlr1 Receptor 0.12 0.11 0.19 1.3E-04 3.5E-04 2.2E-02
Trat1 Receptor 0.12 0.15 0.25 1.3E-04 2.2E-03 4.3E-02
Edg1 Receptor 0.10 0.17 0.13 2.9E-04 1.0E-02 3.0E-02
Il2ra (CD25) CR 48.4 66.9 28.1 1.7E-05 1.2E-05 2.7E-03
Il2rb (CD122) CR 7.1 4.3 1.9 1.4E-03 1.4E-03 2.7E-01
Il7r CR 0.12 0.17 0.05 3.4E-04 1.0E-04 4.9E-03
Il6ra CR 0.11 0.26 0.16 6.3E-06 1.0E-02 9.2E-03
Il6st CR 0.08 0.11 0.16 2.7E-07 3.7E-05 5.3E-03
Sema6d Costimulation 6.1 0.9 1.4 2.1E-02 3.2E-01 2.5E-01
Pdcd1 Costimulation 4.5 4.0 4.6 8.3E-03 5.2E-03 1.7E-02
Ptger2 Costimulation 4.5 18.3 5.3 1.1E-04 6.8E-05 1.5E-02
Cd28 Costimulation 4.0 6.3 2.2 2.0E-03 2.6E-04 1.1E-01
Cd80 Costimulation 3.6 2.1 1.3 7.8E-03 5.3E-03 4.7E-01
Cd24a Costimulation 0.03 0.82 0.78 4.2E-04 2.8E-01 6.4E-01
Ccr5 CCR 18.3 3.9 1.6 1.1E-05 4.3E-04 1.4E-01
Ccr2 CCR 15.7 0.7 0.5 2.4E-04 6.1E-02 4.0E-02
Cxcr6 CCR 5.0 1.9 0.1 5.5E-03 1.9E-01 3.6E-02
Ccr7 CCR 0.10 0.39 1.43 1.1E-03 6.2E-02 7.0E-01
Cxcr4 CCR 0.06 0.46 0.10 6.3E-06 2.1E-02 9.2E-03
Ccr9 CCR 0.03 0.03 0.04 3.1E-07 7.6E-06 2.7E-03
Adam8 Adhesion 16.9 6.1 0.8 3.9E-04 4.4E-03 4.5E-01
Tjp1 Adhesion 14.6 0.4 0.4 2.9E-05 6.7E-03 5.0E-02
Emp1 Adhesion 14.4 13.7 1.3 1.2E-03 2.2E-03 6.3E-01
Emilin2 Adhesion 13.6 0.8 1.1 2.4E-04 2.0E-01 7.6E-01
Itgav Adhesion 10.6 3.6 2.3 3.6E-05 1.0E-03 8.1E-02
Nov Adhesion 10.6 1.0 1.1 1.4E-02 4.3E-01 7.5E-01
Alcam Adhesion 8.2 18.3 8.5 3.0E-04 2.9E-04 1.9E-02
Cdh1 Adhesion 6.9 0.8 0.9 3.3E-03 8.6E-02 6.2E-01
Adam9 Adhesion 6.9 7.1 2.3 4.0E-04 1.2E-03 2.6E-01
Tjp2 Adhesion 5.7 4.7 2.0 1.8E-04 9.1E-05 1.0E-01
Dsc2 Adhesion 5.0 0.9 0.9 5.8E-02 2.0E-01 7.1E-01
Itga6 Adhesion 0.14 0.12 0.48 4.2E-04 1.6E-04 1.5E-01
Itgae Adhesion 0.08 0.10 0.09 3.8E-06 7.1E-05 4.2E-03
Sell (CD62L) Adhesion 0.04 0.23 0.19 2.4E-04 3.6E-04 1.4E-02
  1. NKT, CD8+ NKT-like cells; nCD8, naïve CD8+ T cells; cCD4, cultured CD4+ T cells; aCD8, activated CD8+ T cells. CCR, chemokine receptor; CR, cytokine receptor.