Table 5 Gene expression levels for genes encoding critical surface markers
Symbol | Function | NKT/nCD8 | CD4/nCD8 | aCD8/nCD8 | NKT/nCD8 (q) | CD4/nCD8 (q) | aCD8/nCD8 (q) |
|---|---|---|---|---|---|---|---|
Ifitm1 | Suppression | 89.9 | 7.1 | 1.5 | 2.8E-07 | 2.2E-03 | 2.4E-01 |
Lilrb4 (ILT3) | Suppression | 50.3 | 43.8 | 7.6 | 3.6E-04 | 4.0E-05 | 5.6E-03 |
Ifitm2 | Suppression | 45.6 | 11.4 | 1.6 | 6.0E-07 | 2.1E-03 | 2.8E-01 |
Havcr2 (Tim3) | Suppression | 36.5 | 10.4 | 0.7 | 1.6E-04 | 2.0E-03 | 2.4E-01 |
Tnfrsf9 (4-1BB) | Suppression | 28.2 | 12.5 | 12.8 | 2.4E-04 | 3.2E-03 | 1.1E-02 |
Tnfsf6 (FASL) | Suppression | 24.4 | 4.3 | 3.2 | 1.2E-05 | 6.1E-02 | 4.5E-02 |
Ifitm3 | Suppression | 24.3 | 15.6 | 0.8 | 2.5E-05 | 1.4E-03 | 6.6E-01 |
Ctla4 | Suppression | 5.3 | 18.7 | 21.5 | 2.8E-03 | 4.8E-03 | 2.7E-03 |
Tnfrsf18 (GITR) | Suppression | 4.8 | 11.1 | 4.4 | 2.7E-03 | 4.3E-05 | 1.7E-02 |
Pdcd1lg2 | Suppression | 4.6 | 7.3 | 3.3 | 5.4E-04 | 2.5E-04 | 3.0E-02 |
Icos | Suppression | 4.6 | 4.0 | 3.6 | 2.8E-03 | 3.5E-03 | 3.2E-02 |
Tnfsf11 (RANKL) | Suppression | 3.9 | 8.1 | 27.0 | 7.6E-03 | 2.4E-03 | 3.4E-03 |
Tnfsf10 (TRAIL) | Suppression | 3.1 | 3.2 | 1.8 | 2.7E-03 | 9.5E-03 | 6.6E-02 |
Tnfrsf4 (OX40) | Suppression | 3.0 | 23.8 | 11.3 | 1.6E-02 | 7.6E-06 | 5.7E-03 |
P2ry14 (Gpr105) | Receptor | 65.4 | 6.9 | 1.1 | 2.1E-05 | 2.3E-03 | 6.8E-01 |
Fcer1g | Receptor | 12.7 | 0.7 | 0.7 | 7.4E-04 | 1.4E-02 | 2.2E-01 |
Ptger3 | Receptor | 12.0 | 1.2 | 1.1 | 3.5E-04 | 2.3E-01 | 6.9E-01 |
Il12rb1 | Receptor | 10.6 | 11.3 | 4.0 | 8.9E-04 | 2.7E-05 | 1.8E-02 |
Ltb4r1 | Receptor | 8.8 | 1.2 | 0.9 | 2.9E-03 | 1.8E-01 | 7.0E-01 |
Gabarapl1 | Receptor | 8.7 | 5.3 | 3.4 | 2.4E-04 | 1.8E-03 | 1.4E-01 |
Ly6a | Receptor | 7.3 | 11.3 | 3.0 | 3.5E-04 | 1.7E-04 | 5.3E-02 |
Tcrg | Receptor | 6.3 | 0.2 | 0.3 | 1.9E-03 | 1.4E-03 | 6.9E-02 |
Il12rb2 | Receptor | 5.8 | 18.2 | 6.2 | 1.1E-04 | 1.6E-04 | 1.0E-02 |
Pilrb | Receptor | 5.8 | 0.9 | 0.8 | 1.1E-03 | 1.5E-01 | 5.2E-01 |
Tmem2 | Receptor | 5.8 | 4.6 | 2.0 | 5.4E-03 | 8.5E-04 | 1.1E-01 |
Gpr171 | Receptor | 4.6 | 7.4 | 2.9 | 8.8E-03 | 1.3E-03 | 1.2E-01 |
Gpr34 | Receptor | 4.5 | 0.6 | 0.7 | 2.7E-02 | 1.1E-02 | 3.6E-01 |
Gpr160 | Receptor | 3.7 | 1.1 | 1.4 | 4.8E-03 | 3.0E-01 | 3.5E-01 |
Oprm1 | Receptor | 0.20 | 0.08 | 0.49 | 1.6E-03 | 3.6E-04 | 1.1E-01 |
Tlr1 | Receptor | 0.12 | 0.11 | 0.19 | 1.3E-04 | 3.5E-04 | 2.2E-02 |
Trat1 | Receptor | 0.12 | 0.15 | 0.25 | 1.3E-04 | 2.2E-03 | 4.3E-02 |
Edg1 | Receptor | 0.10 | 0.17 | 0.13 | 2.9E-04 | 1.0E-02 | 3.0E-02 |
Il2ra (CD25) | CR | 48.4 | 66.9 | 28.1 | 1.7E-05 | 1.2E-05 | 2.7E-03 |
Il2rb (CD122) | CR | 7.1 | 4.3 | 1.9 | 1.4E-03 | 1.4E-03 | 2.7E-01 |
Il7r | CR | 0.12 | 0.17 | 0.05 | 3.4E-04 | 1.0E-04 | 4.9E-03 |
Il6ra | CR | 0.11 | 0.26 | 0.16 | 6.3E-06 | 1.0E-02 | 9.2E-03 |
Il6st | CR | 0.08 | 0.11 | 0.16 | 2.7E-07 | 3.7E-05 | 5.3E-03 |
Sema6d | Costimulation | 6.1 | 0.9 | 1.4 | 2.1E-02 | 3.2E-01 | 2.5E-01 |
Pdcd1 | Costimulation | 4.5 | 4.0 | 4.6 | 8.3E-03 | 5.2E-03 | 1.7E-02 |
Ptger2 | Costimulation | 4.5 | 18.3 | 5.3 | 1.1E-04 | 6.8E-05 | 1.5E-02 |
Cd28 | Costimulation | 4.0 | 6.3 | 2.2 | 2.0E-03 | 2.6E-04 | 1.1E-01 |
Cd80 | Costimulation | 3.6 | 2.1 | 1.3 | 7.8E-03 | 5.3E-03 | 4.7E-01 |
Cd24a | Costimulation | 0.03 | 0.82 | 0.78 | 4.2E-04 | 2.8E-01 | 6.4E-01 |
Ccr5 | CCR | 18.3 | 3.9 | 1.6 | 1.1E-05 | 4.3E-04 | 1.4E-01 |
Ccr2 | CCR | 15.7 | 0.7 | 0.5 | 2.4E-04 | 6.1E-02 | 4.0E-02 |
Cxcr6 | CCR | 5.0 | 1.9 | 0.1 | 5.5E-03 | 1.9E-01 | 3.6E-02 |
Ccr7 | CCR | 0.10 | 0.39 | 1.43 | 1.1E-03 | 6.2E-02 | 7.0E-01 |
Cxcr4 | CCR | 0.06 | 0.46 | 0.10 | 6.3E-06 | 2.1E-02 | 9.2E-03 |
Ccr9 | CCR | 0.03 | 0.03 | 0.04 | 3.1E-07 | 7.6E-06 | 2.7E-03 |
Adam8 | Adhesion | 16.9 | 6.1 | 0.8 | 3.9E-04 | 4.4E-03 | 4.5E-01 |
Tjp1 | Adhesion | 14.6 | 0.4 | 0.4 | 2.9E-05 | 6.7E-03 | 5.0E-02 |
Emp1 | Adhesion | 14.4 | 13.7 | 1.3 | 1.2E-03 | 2.2E-03 | 6.3E-01 |
Emilin2 | Adhesion | 13.6 | 0.8 | 1.1 | 2.4E-04 | 2.0E-01 | 7.6E-01 |
Itgav | Adhesion | 10.6 | 3.6 | 2.3 | 3.6E-05 | 1.0E-03 | 8.1E-02 |
Nov | Adhesion | 10.6 | 1.0 | 1.1 | 1.4E-02 | 4.3E-01 | 7.5E-01 |
Alcam | Adhesion | 8.2 | 18.3 | 8.5 | 3.0E-04 | 2.9E-04 | 1.9E-02 |
Cdh1 | Adhesion | 6.9 | 0.8 | 0.9 | 3.3E-03 | 8.6E-02 | 6.2E-01 |
Adam9 | Adhesion | 6.9 | 7.1 | 2.3 | 4.0E-04 | 1.2E-03 | 2.6E-01 |
Tjp2 | Adhesion | 5.7 | 4.7 | 2.0 | 1.8E-04 | 9.1E-05 | 1.0E-01 |
Dsc2 | Adhesion | 5.0 | 0.9 | 0.9 | 5.8E-02 | 2.0E-01 | 7.1E-01 |
Itga6 | Adhesion | 0.14 | 0.12 | 0.48 | 4.2E-04 | 1.6E-04 | 1.5E-01 |
Itgae | Adhesion | 0.08 | 0.10 | 0.09 | 3.8E-06 | 7.1E-05 | 4.2E-03 |
Sell (CD62L) | Adhesion | 0.04 | 0.23 | 0.19 | 2.4E-04 | 3.6E-04 | 1.4E-02 |