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Table 4 Expression of genes encoding secreted molecules with potential suppressive function

From: The IL-10 and IFN-γ pathways are essential to the potent immunosuppressive activity of cultured CD8+NKT-like cells

Symbol

Function

NKT/nCD8

CD4/nCD8

aCD8/nCD8

NKT/nCD8 (q)

CD4/nCD8 (q)

aCD8/nCD8 (q)

Spp1

Suppression

251.4

203.8

7.4

9.9E-06

2.6E-06

1.2E-02

Lgals3 (Gal3)

Suppression

87.0

38.5

3.1

2.6E-07

1.7E-04

4.9E-02

Esm1

Suppression

74.5

2.8

1.2

4.2E-04

2.2E-02

5.8E-01

Fgl2

Suppression

32.7

0.9

0.9

9.2E-05

3.0E-01

6.3E-01

Tnfrsf11b (Opg)

Suppression

29.0

1.1

1.1

2.4E-04

3.0E-01

7.0E-01

Lgals1 (Gal1)

Suppression

27.1

22.3

6.0

1.4E-04

7.8E-04

6.1E-02

Gzmd

Killing

834.8

25.8

1.1

2.1E-07

1.0E-02

6.6E-01

Gzme

Killing

524.9

27.3

0.9

2.3E-06

6.8E-03

6.4E-01

Gzmc

Killing

446.4

25.7

2.1

2.7E-07

3.3E-02

1.8E-01

Gzmg

Killing

328.8

5.5

1.0

1.2E-05

1.8E-02

8.0E-01

Gzmb

Killing

104.6

60.2

85.6

2.2E-06

2.4E-04

2.8E-03

Gzmf

Killing

63.5

1.8

1.3

6.9E-04

9.4E-03

4.1E-01

Gzma

Killing

61.5

17.1

0.4

1.2E-05

6.8E-03

1.2E-01

Prf1

Killing

29.0

1.0

1.7

4.4E-04

4.1E-01

2.8E-01

Gzmk

Killing

23.3

0.5

0.6

1.5E-04

1.7E-02

2.7E-01

Ifng

Cytokine

51.2

50.3

258.7

3.3E-03

1.5E-02

8.2E-04

Il10

Cytokine

47.2

122.8

2.1

1.8E-03

1.6E-05

4.0E-02

Il24

Cytokine

5.5

33.0

1.0

5.1E-02

3.5E-04

8.1E-01

Lta

Cytokine

3.9

5.1

27.8

3.1E-03

2.2E-04

2.7E-03

Ccl3

Chemokine

86.2

162.4

177.9

3.4E-04

1.2E-03

1.3E-03

Ccl4

Chemokine

25.5

20.8

18.7

6.6E-04

3.5E-03

4.1E-03

Ccl9

Chemokine

11.3

53.7

4.4

1.5E-02

5.2E-04

4.5E-02

Cklfsf7

Chemokine

4.7

1.2

0.9

3.4E-03

1.8E-01

7.1E-01

  1. NKT, CD8+ NKT-like cells; nCD8, naïve CD8+ T cells; cCD4, cultured CD4+ T cells; aCD8, activated CD8+ T cells.