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Table 3 Transcription factors differentially expressed in CD8+ NKT-like cells

From: The IL-10 and IFN-γ pathways are essential to the potent immunosuppressive activity of cultured CD8+NKT-like cells

Symbol Function NKT/nCD8 CD4/nCD8 aCD8/nCD8 NKT/nCD8 (q) CD4/nCD8 (q) aCD8/nCD8 (q)
Nfil3 NF 19.7 22.3 4.3 4.0E-04 3.6E-04 3.4E-02
Mycn (Nmyc1) TF 20.8 2.2 1.1 8.0E-05 2.7E-02 6.8E-01
Irf8 (Icsbp1) TF 14.4 1.9 19.2 1.7E-04 3.2E-02 3.7E-03
Irf4 TF 4.7 24.7 18.2 1.6E-03 4.7E-05 6.2E-03
Litaf TF 10.3 5.0 4.8 4.5E-05 1.4E-04 1.6E-02
Runx2 TF 8.6 3.5 1.8 2.2E-04 5.2E-02 3.4E-01
Pbx3 TF 5.8 6.2 1.6 4.1E-04 4.8E-04 3.6E-01
Jun (AP1) TF 5.8 2.9 2.6 8.9E-04 8.8E-02 1.2E-01
Cgrrf1 TF 4.9 4.9 2.8 2.2E-04 2.7E-03 7.7E-02
Eomes TF 4.0 0.2 0.6 9.7E-04 3.8E-04 4.5E-01
Atf4 TF 3.8 2.0 3.1 6.4E-03 3.1E-03 2.0E-02
Zbtb32 (Rog) TF (ZF) 9.3 1.8 3.9 1.2E-03 3.9E-02 1.6E-02
Zdhhc2 TF (ZF) 4.9 2.6 1.5 9.3E-04 1.5E-03 4.6E-01
Zfp313 TF (ZF) 4.3 2.2 1.2 1.9E-02 6.6E-03 6.8E-01
Zfp608 TF (ZF) 3.9 1.2 1.7 4.2E-04 1.1E-01 1.3E-01
Rnf128 TF (RF) 6.2 10.4 1.0 5.8E-04 7.8E-04 8.0E-01
Rnf13 TF (RF) 4.0 1.7 1.2 8.5E-04 7.3E-02 7.0E-01
Socs2 Suppressor 48.6 104.0 27.8 3.5E-05 3.3E-05 3.9E-03
Cish (Socs) Suppressor 8.8 9.5 4.9 1.2E-04 5.2E-05 1.3E-02
Tcf7 TF 0.012 0.061 0.274 5.7E-07 1.4E-03 7.7E-02
Klf3 TF (KR) 0.012 0.014 0.034 9.4E-08 5.9E-06 8.1E-03
Klf2 TF (KR) 0.04 0.03 0.01 4.3E-04 5.5E-04 2.7E-03
Klf1 TF (KR) 0.05 0.05 0.06 3.5E-05 1.7E-04 1.0E-02
Rkhd3 TF (RF) 0.15 0.17 0.16 1.1E-04 1.7E-04 9.1E-03
Bcl11a TF (ZF) 0.15 0.16 0.15 2.4E-04 1.1E-03 2.3E-02
Zbtb20 TF (ZF) 0.20 0.15 0.16 1.2E-04 3.2E-04 6.3E-03
  1. NKT, CD8+ NKT-like cells; nCD8, naïve CD8+ T cells; cCD4, cultured CD4+ T cells; aCD8, activated CD8+ T cells. KR, Kruppel-like factor; NF, nuclear factor; RF, ring finger; TF, transcription factor; ZF, zinc finger. The table is split into two parts based on the expression ratio of NKT/nCD8.