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Table 3 Example genes from the consensus sets of groups 1-3 ordered by their average rank across all DTs

From: Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers

  ProbeID Average rank Gene symbol Description
Consensus group 1     
   Early 201577_at 627.1 NME1* Non-metastatic cells 1, protein (NM23A)
  200812_at 633.8 CCT7 Chaperonin containing TCP1, subunit 7 (eta)
  201202_at 875.7 PCNA Proliferating cell nuclear antigen
  205436_s_at 890.0 H2AFX H2A histone family, member X
  201476_s_at 904.6 RRM1 Ribonucleotide reductase M1 polypeptide
  200910_at 922.9 CCT3 Chaperonin containing TCP1, subunit 3 (gamma)
  202330_s_at 924.1 UNG Uracil-DNA glycosylase
  202503_s_at 1060.0 KIAA0101* KIAA0101
  222077_s_at 1146.2 RACGAP1 Rac GTPase activating protein 1
  204170_s_at 1188.5 CKS2 CDC28 protein kinase regulatory subunit 2
Consensus group 2     
   Early 204766_s_at 530.6 NUDT1 Nudix (nucleoside diphosphate linked moiety X)-type motif 1
  204825_at 629.0 MELK Maternal embryonic leucine zipper kinase
  203270_at 636.6 DTYMK Deoxythymidylate kinase (thymidylate kinase)
  218585_s_at 768.5 DTL Denticleless homolog (Drosophila)
  220085_at 772.6 HELLS Helicase, lymphoid-specific
   Late 205741_s_at 3587.9 DTNA Dystrobrevin, alpha
  204279_at 3816.5 PSMB9 Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
  204416_x_at 3944.6 APOC1 Apolipoprotein C-I
  202307_s_at 3987.2 TAP1 Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
  209040_s_at 4243.6 PSMB8 Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
Consensus group 3     
   Early 204825_at 629.0 MELK Maternal embryonic leucine zipper kinase
  202503_s_at 1060.0 KIAA0101* KIAA0101
  202705_at 1095.9 CCNB2 Cyclin B2
  222077_s_at 1146.2 RACGAP1 Rac GTPase activating protein 1
  204170_s_at 1188.5 CKS2 CDC28 protein kinase regulatory subunit 2
   Late 208997_s_at 3296.1 UCP2 Uncoupling protein 2 (mitochondrial, proton carrier)
  205798_at 3499.9 MMP7 Matrix metallopeptidase 7 (matrilysin, uterine)
  202307_s_at 3724.7 PPGB Protective protein for beta-galactosidase (galactosialidosis)
  209166_s_at 3946.3 IL7R Interleukin 7 receptor
  206707_x_at 3987.2 TAP1 Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
  208812_x_at 4485.7 HLA-C Major histocompatibility complex, class I, C
  1. To identify only the most relevant genes, the definition of 'consensus gene set' was tightened from the definition employed in Figure 7. Consensus group 1 = 20 genes overexpressed in at least 15/16 data sets belonging to group 1; consensus group 2 = 58 genes overexpressed in all data sets (6/6) belonging to group 2; consensus group 3 = 29 genes overexpressed in 9/13 data sets belonging to group 3. Bold entries are those expressed more than three times above median in at least one of murine E6, E7, E8, E9, E10 (Symatlas). Italicized entries are those expressed more than three times above median in at least one of the following human cell types: CD4+ T cells, CD8+ T cells, CD19+ B cells (peripheral blood), BDCA4+ dendritic cells, B lymphoblasts (peripheral blood). *Expression data not available in Symatlas.
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Genome Biology

ISSN: 1474-760X

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