| BP - overrepresented | BP - underrepresented | CC - overrepresented |
---|---|---|---|
eDEV500 | DNA replication Cell cycle RNA splicing DNA repair Chromatin modification | Multicellular organismal process Cell communication Signal transduction System development Ion transport | Intracellular Nuclear part Membrane-bound organelle Spliceosome Ribonucleoprotein complex |
lDEV500 | Immune response Antigen processing and presentation Cytokine and chemokine mediated signaling pathway Cell adhesion Multicellular organismal process | Biopolymer metabolic process Biosynthetic process RNA processing Cell cycle phase DNA repair | Membrane Extracellular region MHC protein complex Lysosome Secretory granule |
Group 1 (16) | Â | Â | Â |
   Up | DNA repair (15) Cell cycle (15) RNA splicing (13) | Multicellular organismal process (16) G-protein coupled receptor protein signaling pathway (16) Neurological process (16) | Intracellular (16) Organelle (15) Nuclear part (15) |
   Down | Multicellular organismal process (15) Organ development (14) Cell communication (11) | Primary metabolic process (14) RNA processing (14) DNA metabolic process (14) | Plasma membrane (16) Extracellular region (13) Voltage-gated potassium channel complex (8) |
Group 2 (6) | Â | Â | Â |
   Up | Cell cycle (6) DNA replication (6) Response to DNA damage stimulus (6) | Multicellular organismal development (5) Anatomical structure development (5) System development (4) | Chromosome (6) Protein complex (5) Replication fork (5) |
   Down | Monovalent inorganic cation transport (5) ATP synthesis coupled proton transport (5) Oxidative phosphorylation (4) | DNA recombination (6) Immune response (5) Macromolecule metabolic process (5) | Proton-transporting two-sector ATPase complex (5) Membrane (5) Extracellular matrix (3) |
Group 3 (13) | Â | Â | Â |
   Up | Immune response (10) Multicellular organismal process (8) Cell adhesion (6) Response to wounding (5) | Cellular metabolic process (10) Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process (9) RNA metabolic process (8) | Plasma membrane (10) Extracellular region (10) Lysosome (5) |
   Down | Cellular metabolic process (10) Protein metabolic process (6) RNA processing (5) | Multicellular organismal process (10) Immune response (10) Cell activation (8) | Cytoplasm (10) Intracellular (8) Organelle (8) |
PEN versus ESEN | Â | Â | Â |
   Up | DNA replication Cell cycle phase DNA metabolic process | Biosynthetic process Generation of precursor metabolites and energy Translation | Chromosome Replication fork Microtubule cytoskeleton |
   Down | Lipid metabolic process Lipid biosynthetic process Cofactor metabolic process | Macromolecule metabolic process Intracellular signaling cascade M phase of mitotic cell cycle | Desmosome Membrane fraction Microsome |