Table 1 GO category enrichment
| BP - overrepresented | BP - underrepresented | CC - overrepresented | |
|---|---|---|---|
| eDEV500 |
DNA replication Cell cycle RNA splicing DNA repair Chromatin modification |
Multicellular organismal process Cell communication Signal transduction System development Ion transport |
Intracellular Nuclear part Membrane-bound organelle Spliceosome Ribonucleoprotein complex |
| lDEV500 |
Immune response Antigen processing and presentation Cytokine and chemokine mediated signaling pathway Cell adhesion Multicellular organismal process |
Biopolymer metabolic process Biosynthetic process RNA processing Cell cycle phase DNA repair |
Membrane Extracellular region MHC protein complex Lysosome Secretory granule |
| Group 1 (16) | |||
| Up |
DNA repair (15) Cell cycle (15) RNA splicing (13) |
Multicellular organismal process (16) G-protein coupled receptor protein signaling pathway (16) Neurological process (16) |
Intracellular (16) Organelle (15) Nuclear part (15) |
| Down |
Multicellular organismal process (15) Organ development (14) Cell communication (11) |
Primary metabolic process (14) RNA processing (14) DNA metabolic process (14) |
Plasma membrane (16) Extracellular region (13) Voltage-gated potassium channel complex (8) |
| Group 2 (6) | |||
| Up |
Cell cycle (6) DNA replication (6) Response to DNA damage stimulus (6) |
Multicellular organismal development (5) Anatomical structure development (5) System development (4) |
Chromosome (6) Protein complex (5) Replication fork (5) |
| Down |
Monovalent inorganic cation transport (5) ATP synthesis coupled proton transport (5) Oxidative phosphorylation (4) |
DNA recombination (6) Immune response (5) Macromolecule metabolic process (5) |
Proton-transporting two-sector ATPase complex (5) Membrane (5) Extracellular matrix (3) |
| Group 3 (13) | |||
| Up |
Immune response (10) Multicellular organismal process (8) Cell adhesion (6) Response to wounding (5) |
Cellular metabolic process (10) Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process (9) RNA metabolic process (8) |
Plasma membrane (10) Extracellular region (10) Lysosome (5) |
| Down |
Cellular metabolic process (10) Protein metabolic process (6) RNA processing (5) |
Multicellular organismal process (10) Immune response (10) Cell activation (8) |
Cytoplasm (10) Intracellular (8) Organelle (8) |
| PEN versus ESEN | |||
| Up |
DNA replication Cell cycle phase DNA metabolic process |
Biosynthetic process Generation of precursor metabolites and energy Translation |
Chromosome Replication fork Microtubule cytoskeleton |
| Down |
Lipid metabolic process Lipid biosynthetic process Cofactor metabolic process |
Macromolecule metabolic process Intracellular signaling cascade M phase of mitotic cell cycle |
Desmosome Membrane fraction Microsome |