TY - JOUR AU - Naxerova, Kamila AU - Bult, Carol J. AU - Peaston, Anne AU - Fancher, Karen AU - Knowles, Barbara B. AU - Kasif, Simon AU - Kohane, Isaac S. PY - 2008 DA - 2008/07/08 TI - Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers JO - Genome Biology SP - R108 VL - 9 IS - 7 AB - In recent years, the molecular underpinnings of the long-observed resemblance between neoplastic and immature tissue have begun to emerge. Genome-wide transcriptional profiling has revealed similar gene expression signatures in several tumor types and early developmental stages of their tissue of origin. However, it remains unclear whether such a relationship is a universal feature of malignancy, whether heterogeneities exist in the developmental component of different tumor types and to which degree the resemblance between cancer and development is a tissue-specific phenomenon. SN - 1474-760X UR - https://doi.org/10.1186/gb-2008-9-7-r108 DO - 10.1186/gb-2008-9-7-r108 ID - Naxerova2008 ER -