Figure 4

Correlation between maximum structure vulnerability ν and co-expression similarity η for yeast protein interactions. (a) Correlation between maximum structure vulnerability ν and co-expression similarity η for interactions within specific yeast complexes. The ν-parameter of an interaction is defined as the maximum vulnerability between the two interacting partners, and the η-parameter is the ratio of their expression correlation to the (non-zero) expected correlation over all interacting pairs in the proteome. (b) (η-ν) correlation for all Pfam-filtered yeast protein interactions. Red points represent interactions involving extremely vulnerable proteins, including confirmed yeast prions (Additional data file 5). (c) (η-ν) correlation of Pfam-filtered yeast protein interactions involving only PDB-reported proteins. The red data point represents an interaction involving an extremely vulnerable protein, and the green point represents an interaction involving an extremely vulnerable protein reported to be a prion protein (ERF2) [24–26].