Figure 2

A cartoon illustrating the method used here for identifying post-macaque SDs based on chromosomal synteny. Using the liftOver tool [29] from the UCSC genome browser group, a pair of human SDs (A and B) is mapped to the same location (A') in the macaque genome. A and B (large block) are thus considered the product of an SD event that occurred after the split of human from macaque lineages. Then 1 kb sequences (small block) adjacent to A or B were aligned to the macaque genome. If only the sequence next to A was mapped next to A', then A is designated as the parental copy and B as the derivative.