Skip to main content

Table 3 Summary of SAGE tag K-means cluster data

From: Identification of transcripts with enriched expression in the developing and adult pancreas

Cluster Number of tags in the cluster Number of genes in the cluster Number of genome maps in the cluster Number assessed by GenePaint* Number assessed by QPCR Median S Previously characterized genes in the cluster Selected GO categories and KEGG pathways enriched in the cluster
1 154 85 61 37 3 0.0079 Nkx6-2 Transcriptional activator activity p = 0.02; development p = 0.049
2 49 29 19 15 2 0.0037   Metabolism p = 0.01; cell organization and biogenesis p = 0.035
3 58 40 15 14 2 0.0044   Receptor activity p = 0.028; development p = 0.030
4 292 115 175 45 4 0.00895 Hes6, Pdx1, Sox9 Regulation of transcription p = 0.027; maturity onset diabetes of the young p = 0.002
5 1,008 427 542 175 13 0.03555 Arx, Gcg, Ghrl, Iapp, Isl1, Nkx2-2, Myt1, Neurog3, Neurod1, Pax4, Pax6, Pou3f4, Pyy Secretory pathway p < 0.001; hormone activity p = 0.049; maturity onset diabetes of the young p < 0.001
6 60 41 17 16 1 0.00465   
7 21 11 10 7 1 0.008   
8 78 46 28 29 5 0.012 Pax6 Eye morphogenesis p = 0.020; type II diabetes mellitus p = 0.001
9 23 16 6 10 2 0.0041   Cell proliferation p = 0.028
10 401 281 107 122 4 0.0158 Id2 Response to endogenous stimulus p = 0.021
11 76 57 10 23 1 0.00555 Amy1, Cel, Clps, Ela1, Pnliprp2, Reg1 Protein catabolism p = 0.002
12 154 122 13 56 3 0.0074 Ela1, Pnlip, Reg3d Growth factor binding p = 0.005; carboxypeptidase activity p = 0.013; regulation of cell growth p = 0.027
13 136 84 42 30 3 0.01835 Iapp, Ins1, Ins2 Secretion p = 0.03; maturity onset diabetes of the young p < 0.001; type II diabetes mellitus p < 0.001; type I diabetes mellitus p = 0.003
14 56 47 4 22 0 0.00335   Protein metabolism p = 0.020
  1. *Refers to the number of genes analyzed by in situ hybridization using GenePaint [62] on TS22 whole embryo cryo-sections that gave informative staining. S is the specificity of the tag. Specificity is calculated as described in the Materials and methods. GO term enrichments and p-values were calculated using EASE while KEGG pathway enrichments and p-values using Webgestalt as described in the Materials and methods.