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Table 3 Summary of SAGE tag K-means cluster data

From: Identification of transcripts with enriched expression in the developing and adult pancreas

Cluster

Number of tags in the cluster

Number of genes in the cluster

Number of genome maps in the cluster

Number assessed by GenePaint*

Number assessed by QPCR

Median S†

Previously characterized genes in the cluster

Selected GO categories and KEGG pathways enriched in the cluster‡

1

154

85

61

37

3

0.0079

Nkx6-2

Transcriptional activator activity p = 0.02; development p = 0.049

2

49

29

19

15

2

0.0037

 

Metabolism p = 0.01; cell organization and biogenesis p = 0.035

3

58

40

15

14

2

0.0044

 

Receptor activity p = 0.028; development p = 0.030

4

292

115

175

45

4

0.00895

Hes6, Pdx1, Sox9

Regulation of transcription p = 0.027; maturity onset diabetes of the young p = 0.002

5

1,008

427

542

175

13

0.03555

Arx, Gcg, Ghrl, Iapp, Isl1, Nkx2-2, Myt1, Neurog3, Neurod1, Pax4, Pax6, Pou3f4, Pyy

Secretory pathway p < 0.001; hormone activity p = 0.049; maturity onset diabetes of the young p < 0.001

6

60

41

17

16

1

0.00465

  

7

21

11

10

7

1

0.008

  

8

78

46

28

29

5

0.012

Pax6

Eye morphogenesis p = 0.020; type II diabetes mellitus p = 0.001

9

23

16

6

10

2

0.0041

 

Cell proliferation p = 0.028

10

401

281

107

122

4

0.0158

Id2

Response to endogenous stimulus p = 0.021

11

76

57

10

23

1

0.00555

Amy1, Cel, Clps, Ela1, Pnliprp2, Reg1

Protein catabolism p = 0.002

12

154

122

13

56

3

0.0074

Ela1, Pnlip, Reg3d

Growth factor binding p = 0.005; carboxypeptidase activity p = 0.013; regulation of cell growth p = 0.027

13

136

84

42

30

3

0.01835

Iapp, Ins1, Ins2

Secretion p = 0.03; maturity onset diabetes of the young p < 0.001; type II diabetes mellitus p < 0.001; type I diabetes mellitus p = 0.003

14

56

47

4

22

0

0.00335

 

Protein metabolism p = 0.020

  1. *Refers to the number of genes analyzed by in situ hybridization using GenePaint [62] on TS22 whole embryo cryo-sections that gave informative staining. †S is the specificity of the tag. Specificity is calculated as described in the Materials and methods. ‡GO term enrichments and p-values were calculated using EASE while KEGG pathway enrichments and p-values using Webgestalt as described in the Materials and methods.