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Table 2 Human SuperArray data showing greater than twofold cell cycle RNA expression changes in NAD-treated HEK293 cells compared with controls

From: Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)

Gene name

Symbol

Acc. Number

Array cell

Fold change

SD

Cell cycle function

V-abl Abelson murine leukemia viral oncogene homolog 1

ABL1

NM_005157

A01

18.25

3.19

S phase and DNA replication and regulation

Cullin 2

CUL2

NM_003591

D10

14.32

1.89

G1 phase and G1/S transition and checkpoint and arrest

B-cell CLL/lymphoma 2

BCL2

NM_000633

A09

12.44

2.12

Regulation

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

CDKN2B

NM_004936

D03

11.03

2.37

Checkpoint and arrest and negative regulator

Anaphase promoting complex subunit 4

ANAPC4

NM_013367

A03

9.17

0.27

G2 phase and G2/M transition and regulation

Cullin 3

CUL3

NM_003590

D11

8.46

0.65

G1 phase and G1/S transition and checkpoint and arrest

Cyclin-dependent kinase 5, regulatory subunit 1 (p35)

CDK5R1

NM_003885

C07

8.00

1.66

Regulation

RAD1 homolog

RAD1

NM_002853

F09

7.43

0.48

Checkpoint and arrest

SERTA domain containing 1

SERTAD1

NM_013376

G06

7.41

0.27

G2 phase and G2/M transition

Ataxia telangiectasia and Rad3 related

ATR

NM_001184

A06

6.51

0.36

Checkpoint and arrest

Ubiquitin-activating enzyme E1

UBE1

NM_003334

G12

6.48

1.19

S phase and DNA replication

Dynamin 2

DNM2

NM_004945

E01

5.38

0.37

G2 phase and G2/M transition

Cell division cycle 16 homolog

CDC16

NM_003903

C01

4.94

0.43

M phase

HUS1 checkpoint homolog

HUS1

NM_004507

E07

4.89

0.74

Checkpoint and arrest

Cyclin-dependent kinase 8

CDK8

NM_001260

C11

4.86

1.25

Regulation

RAD51 homolog (RecA homolog)

RAD51

NM_002875

F11

4.77

3.09

M phase

Menage a trois homolog 1, cyclin H assembly factor

MNAT1

NM_002431

F05

4.51

0.18

G2 phase and G2/M transition

Tumor protein p53 (Li-Fraumeni syndrome)

TP53

NM_000546

G11

4.40

1.48

Checkpoint and arrest

Cyclin-dependent kinase 2

CDK2

NM_001798

C05

4.07

0.24

Checkpoint and arrest and regulation

Anaphase promoting complex subunit 2

ANAPC2

NM_013366

A02

3.76

0.63

G1 phase and G1/S transition and regulation

Growth arrest and DNA-damage-inducible, alpha

GADD45A

NM_001924

E03

3.70

0.08

Checkpoint and arrest and regulation

Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

CDKN1B

NM_004064

D01

3.65

0.25

G1 phase and G1/S transition and checkpoint and arrest

Cyclin-dependent kinase inhibitor 3

CDKN3

NM_005192

D04

3.36

0.09

G1+G2 phase and G1/S + G2/M transition and checkpoint and arrest

CDK5 regulatory subunit associated protein 1

CDK5RAP1

NM_016408

C08

3.32

0.06

G2 phase and G2/M transition

Cyclin F

CCNF

NM_001761

B07

3.22

0.20

M phase and regulation

Cyclin-dependent kinase 6

CDK6

NM_001259

C09

3.22

0.23

G1 phase and G1/S transition and regulation

DIRAS family, GTP-binding RAS-like 3

DIRAS3

NM_004675

A04

3.15

0.12

?

CHK1 checkpoint homolog

CHEK1

NM_001274

D05

2.95

0.15

Checkpoint and arrest

Nibrin

NBN

NM_002485

F07

2.89

0.03

Checkpoint and arrest

Retinoblastoma-like 2 (p130)

RBL2

NM_005611

G04

2.89

0.83

Negative regulator

Cell division cycle 34 homolog

CDC34

NM_004359

C04

2.86

0.14

G1 phase and G1/S transition and checkpoint and arrest

Cyclin G2

CCNG2

NM_004354

B09

2.81

0.18

Checkpoint and arrest

BCL2-associated X protein

BAX

NM_004324

A07

2.76

0.06

Negative regulator

Proliferating cell nuclear antigen

PCNA

NM_182649

F08

2.76

0.19

S phase and DNA replication

SMT3 suppressor of mif two 3 homolog 1

SUMO1

NM_003352

G08

2.73

0.10

S phase and DNA replication

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1A

NM_000389

C12

2.67

0.08

Checkpoint and arrest and regulation

Hect domain and RLD 5

HERC5

NM_016323

E06

2.54

0.04

G2 phase and G2/M transition

Cyclin-dependent kinase 4

CDK4

NM_000075

C06

2.52

0.13

G1 phase and G1/S transition and regulation

G-2 and S-phase expressed 1

GTSE1

NM_016426

E05

2.49

0.10

G2 phase and G2/M transition

Cyclin T2

CCNT2

NM_001241

B12

2.41

0.16

G2 phase and G2/M transition and regulation

Breast cancer 2, early onset

BRCA2

NM_000059

A12

2.36

0.27

Checkpoint and arrest and regulation

Retinoblastoma-like 1 (p107)

RBL1

NM_002895

G03

2.31

0.04

Negative regulator

MCM5 minichromosome maintenance deficient 5

MCM5

NM_006739

F03

2.28

0.13

S phase and DNA replication

CDC28 protein kinase regulatory subunit 1B

CKS1B

NM_001826

D07

2.28

0.03

G2 phase and G2/M transition and regulation

Cell division cycle 20 homolog

CDC20

NM_001255

C03

2.24

0.17

Regulation

Cyclin C

CCNC

NM_005190

B03

2.16

0.14

Regulation

MAD2 mitotic arrest deficient-like 2

MAD2L2

NM_006341

E11

2.03

0.46

Checkpoint and arrest

Transcription factor Dp-1

TFDP1

NM_007111

G09

-22.50

1.04

Regulation

  1. NAD, nicotinamide adenine dinucleotide; SD, standard deviation.