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Table 2 Human SuperArray data showing greater than twofold cell cycle RNA expression changes in NAD-treated HEK293 cells compared with controls

From: Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)

Gene name Symbol Acc. Number Array cell Fold change SD Cell cycle function
V-abl Abelson murine leukemia viral oncogene homolog 1 ABL1 NM_005157 A01 18.25 3.19 S phase and DNA replication and regulation
Cullin 2 CUL2 NM_003591 D10 14.32 1.89 G1 phase and G1/S transition and checkpoint and arrest
B-cell CLL/lymphoma 2 BCL2 NM_000633 A09 12.44 2.12 Regulation
Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) CDKN2B NM_004936 D03 11.03 2.37 Checkpoint and arrest and negative regulator
Anaphase promoting complex subunit 4 ANAPC4 NM_013367 A03 9.17 0.27 G2 phase and G2/M transition and regulation
Cullin 3 CUL3 NM_003590 D11 8.46 0.65 G1 phase and G1/S transition and checkpoint and arrest
Cyclin-dependent kinase 5, regulatory subunit 1 (p35) CDK5R1 NM_003885 C07 8.00 1.66 Regulation
RAD1 homolog RAD1 NM_002853 F09 7.43 0.48 Checkpoint and arrest
SERTA domain containing 1 SERTAD1 NM_013376 G06 7.41 0.27 G2 phase and G2/M transition
Ataxia telangiectasia and Rad3 related ATR NM_001184 A06 6.51 0.36 Checkpoint and arrest
Ubiquitin-activating enzyme E1 UBE1 NM_003334 G12 6.48 1.19 S phase and DNA replication
Dynamin 2 DNM2 NM_004945 E01 5.38 0.37 G2 phase and G2/M transition
Cell division cycle 16 homolog CDC16 NM_003903 C01 4.94 0.43 M phase
HUS1 checkpoint homolog HUS1 NM_004507 E07 4.89 0.74 Checkpoint and arrest
Cyclin-dependent kinase 8 CDK8 NM_001260 C11 4.86 1.25 Regulation
RAD51 homolog (RecA homolog) RAD51 NM_002875 F11 4.77 3.09 M phase
Menage a trois homolog 1, cyclin H assembly factor MNAT1 NM_002431 F05 4.51 0.18 G2 phase and G2/M transition
Tumor protein p53 (Li-Fraumeni syndrome) TP53 NM_000546 G11 4.40 1.48 Checkpoint and arrest
Cyclin-dependent kinase 2 CDK2 NM_001798 C05 4.07 0.24 Checkpoint and arrest and regulation
Anaphase promoting complex subunit 2 ANAPC2 NM_013366 A02 3.76 0.63 G1 phase and G1/S transition and regulation
Growth arrest and DNA-damage-inducible, alpha GADD45A NM_001924 E03 3.70 0.08 Checkpoint and arrest and regulation
Cyclin-dependent kinase inhibitor 1B (p27, Kip1) CDKN1B NM_004064 D01 3.65 0.25 G1 phase and G1/S transition and checkpoint and arrest
Cyclin-dependent kinase inhibitor 3 CDKN3 NM_005192 D04 3.36 0.09 G1+G2 phase and G1/S + G2/M transition and checkpoint and arrest
CDK5 regulatory subunit associated protein 1 CDK5RAP1 NM_016408 C08 3.32 0.06 G2 phase and G2/M transition
Cyclin F CCNF NM_001761 B07 3.22 0.20 M phase and regulation
Cyclin-dependent kinase 6 CDK6 NM_001259 C09 3.22 0.23 G1 phase and G1/S transition and regulation
DIRAS family, GTP-binding RAS-like 3 DIRAS3 NM_004675 A04 3.15 0.12 ?
CHK1 checkpoint homolog CHEK1 NM_001274 D05 2.95 0.15 Checkpoint and arrest
Nibrin NBN NM_002485 F07 2.89 0.03 Checkpoint and arrest
Retinoblastoma-like 2 (p130) RBL2 NM_005611 G04 2.89 0.83 Negative regulator
Cell division cycle 34 homolog CDC34 NM_004359 C04 2.86 0.14 G1 phase and G1/S transition and checkpoint and arrest
Cyclin G2 CCNG2 NM_004354 B09 2.81 0.18 Checkpoint and arrest
BCL2-associated X protein BAX NM_004324 A07 2.76 0.06 Negative regulator
Proliferating cell nuclear antigen PCNA NM_182649 F08 2.76 0.19 S phase and DNA replication
SMT3 suppressor of mif two 3 homolog 1 SUMO1 NM_003352 G08 2.73 0.10 S phase and DNA replication
Cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A NM_000389 C12 2.67 0.08 Checkpoint and arrest and regulation
Hect domain and RLD 5 HERC5 NM_016323 E06 2.54 0.04 G2 phase and G2/M transition
Cyclin-dependent kinase 4 CDK4 NM_000075 C06 2.52 0.13 G1 phase and G1/S transition and regulation
G-2 and S-phase expressed 1 GTSE1 NM_016426 E05 2.49 0.10 G2 phase and G2/M transition
Cyclin T2 CCNT2 NM_001241 B12 2.41 0.16 G2 phase and G2/M transition and regulation
Breast cancer 2, early onset BRCA2 NM_000059 A12 2.36 0.27 Checkpoint and arrest and regulation
Retinoblastoma-like 1 (p107) RBL1 NM_002895 G03 2.31 0.04 Negative regulator
MCM5 minichromosome maintenance deficient 5 MCM5 NM_006739 F03 2.28 0.13 S phase and DNA replication
CDC28 protein kinase regulatory subunit 1B CKS1B NM_001826 D07 2.28 0.03 G2 phase and G2/M transition and regulation
Cell division cycle 20 homolog CDC20 NM_001255 C03 2.24 0.17 Regulation
Cyclin C CCNC NM_005190 B03 2.16 0.14 Regulation
MAD2 mitotic arrest deficient-like 2 MAD2L2 NM_006341 E11 2.03 0.46 Checkpoint and arrest
Transcription factor Dp-1 TFDP1 NM_007111 G09 -22.50 1.04 Regulation
  1. NAD, nicotinamide adenine dinucleotide; SD, standard deviation.