Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

Table 1 Hepatotoxicants studied

Compound	Low dose 'sub-toxic' (mg/kg)	Medium dose 'moderately toxic' (mg/kg)	Medium high dose (mg/kg)	High dose 'toxic' (mg/kg)	Vehicle	Delivery method	Primary site of livery injury
Bromobenzene	25	75	NA	250	Corn oil	Oral gavage	Centrilobular
1,2-Dichlorobenzene	15	150	NA	1,500	Corn oil	Oral gavage	Centrilobular
1,4-Dichlorobenzene	15	150	NA	1,500	Corn oil	Oral gavage	NA*
N-nitrosomorpholine	10	50	NA	300	PBS	Oral gavage	Centrilobular
Diquat	5	10	20	25	PBS	Intraperitoneal injection	Mid-zonal to centrilobular
Monocrotaline	10	50	NA	300	PBS	Oral gavage	Centrilobular
Thioacetamide	15	50	NA	150	PBS	Oral gavage	Centrilobular
Galactosamine	25	100	NA	400	PBS	Intra-peritoneal injection	Random

*1, 4-Dichlorobenzene was intended to function as a non-toxic analog of 1,2-dichlorobenezene; however, centrilobular hepatocyte necrosis was observed in one of the six low dose animals at 6 hours and all four of the high dose animals at the 24 hour time point. NA, not applicable; PBS, phosphate-buffered saline.

ISSN: 1474-760X