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Table 1 Hepatotoxicants studied

From: Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

Compound Low dose 'sub-toxic' (mg/kg) Medium dose 'moderately toxic' (mg/kg) Medium high dose (mg/kg) High dose 'toxic' (mg/kg) Vehicle Delivery method Primary site of livery injury
Bromobenzene 25 75 NA 250 Corn oil Oral gavage Centrilobular
1,2-Dichlorobenzene 15 150 NA 1,500 Corn oil Oral gavage Centrilobular
1,4-Dichlorobenzene 15 150 NA 1,500 Corn oil Oral gavage NA*
N-nitrosomorpholine 10 50 NA 300 PBS Oral gavage Centrilobular
Diquat 5 10 20 25 PBS Intraperitoneal injection Mid-zonal to centrilobular
Monocrotaline 10 50 NA 300 PBS Oral gavage Centrilobular
Thioacetamide 15 50 NA 150 PBS Oral gavage Centrilobular
Galactosamine 25 100 NA 400 PBS Intra-peritoneal injection Random
  1. *1, 4-Dichlorobenzene was intended to function as a non-toxic analog of 1,2-dichlorobenezene; however, centrilobular hepatocyte necrosis was observed in one of the six low dose animals at 6 hours and all four of the high dose animals at the 24 hour time point. NA, not applicable; PBS, phosphate-buffered saline.